Association between the geriatric nutritional risk index and adverse post-extubation outcomes for critically ill older adults: a retrospective study

被引：0
作者：
Sheng-chang Ye [1 ]
Yu-ting Mao [2 ]
Bo-li Huang [3 ]
Li-li Hou [1 ]
机构：
[1] Nursing department, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai JiaoTong University School of Nursing, Shanghai
[2] The second department of stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai
[3] Department of emergency, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
来源：
BMC Pulmonary Medicine | / 25卷 / 1期
关键词：
Adverse post-extubation outcomes; Geriatric nutrition risk index; Intensive care; Mortality; Older adults;
D O I：
10.1186/s12890-025-03600-5
中图分类号：
学科分类号：
摘要：
Background and purpose: Malnutrition commonly predicts adverse outcomes among older adults in the intensive care unit (ICU). The Geriatric Nutritional Risk Index (GNRI) is a simple and practical tool for assessing nutritional status in older adults. This study aims to explore the association between GNRI and adverse post-extubation outcomes in critically ill older adults. Methods: A total of 1,153 older adults aged 65–82 years in the ICU were included in this retrospective cohort study. GNRI categories were stratified into four subgroups based on nutritional risk: major risk (GNRI < 82), moderate risk (GNRI 82–91), low risk (GNRI 92–98), and no risk (GNRI > 98). Adverse post-extubation outcomes included mortality or pneumonia within 30 days post-extubation, reintubation within 72 h, post-extubation dysphagia, and length of stay (LOS) in the ICU and hospital. Multivariable logistic regression analysis and restricted cubic spline (RCS) were used to explore the association between GNRI categories and dichotomous adverse outcomes. Additionally, multivariable linear regression was used to evaluate the association between GNRI and LOS in the ICU and hospital. Results: Older adults with dichotomous adverse outcomes had lower GNRI values compared with those without (P-value<0.001), and increasing LOS in ICU and hospital was associated with decreasing GNRI value (P for trend<0.001). Patients at major nutritional risk had the highest risk of mortality [OR = 2.76, 95%CI: 1.40 ∼ 5.46] or pneumonia [OR = 3.07, 95%CI: 1.42 ∼ 6.68] within 30 days post-extubation, reintubation within 72 h [OR = 2.41, 95%CI: 1.06 ∼ 5.49] and post-extubation dysphagia [OR = 2.94, 95%CI: 1.19 ∼ 7.31](P for trend<0.001). The RCS study also validated the linear relationship between GNRI and mortality/pneumonia within 30 days post-extubation and post-extubation dysphagia. Conversely, there were non-linear associations between GNRI and ICU and hospital LOS, as well as reintubation within 72 h. Furthermore, GNRI showed a significant negative correlation with LOS in both the ICU and hospital. Kaplan-Meier curve analysis demonstrated that survival within 30 days post-extubation was significantly reduced in major nutritional risk group compared to the no risk group (P-value = 0.018). Conclusions: Our findings demonstrated that major nutritional risk defined by GNRI was associated with a higher risk of adverse post-extubation outcomes in critically ill older adults. © The Author(s) 2025.
引用
收藏
相关论文
共 37 条
  • [1] Amaral T.F., Matos L.C., Teixeira M.A., Tavares M.M., Alvares L., Antunes A., Undernutrition and associated factors among hospitalized patients, CLIN NUTR, 29, 5, pp. 580-585, (2010)
  • [2] Hill A., Elke G., Weimann A., Nutrition in the intensive care Unit-A narrative review, NUTRIENTS, 13, 8, (2021)
  • [3] Lew C., Yandell R., Fraser R., Chua A.P., Chong M., Miller M., Association between malnutrition and clinical outcomes in the intensive care unit: A systematic review [Formula: see text], JPEN J Parenter Enter Nutr, 41, 5, pp. 744-758, (2017)
  • [4] van Bokhorst-de V.D.S.M., Guaitoli P.R., Jansma E.P., de Vet H.C., Nutrition screening tools: does one size fit all? A systematic review of screening tools for the hospital setting, CLIN NUTR, 33, 1, pp. 39-58, (2014)
  • [5] Molina L.R., Munoz D.B., Martinez-de LIJ, Romero-Saldana M., Molina R.G., [Is the Spanish short version of mini nutritional assessment (MNA-SF) valid for nutritional screening of the elderly?], Nutr Hosp, 36, 2, pp. 290-295, (2019)
  • [6] Kaiser M.J., Bauer J.M., Ramsch C., Uter W., Guigoz Y., Cederholm T., Thomas D.R., Anthony P., Charlton K.E., Maggio M., Et al., Validation of the mini nutritional assessment short-form (MNA-SF): a practical tool for identification of nutritional status, J NUTR HEALTH AGING, 13, 9, pp. 782-788, (2009)
  • [7] McClave S.A., Taylor B.E., Martindale R.G., Warren M.M., Johnson D.R., Braunschweig C., McCarthy M.S., Davanos E., Rice T.W., Cresci G.A., Et al., Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: society of critical care medicine (SCCM) and American society for parenteral and enteral nutrition (A.S.P.E.N), JPEN J Parenter Enter Nutr, 40, 2, pp. 159-211, (2016)
  • [8] Kondrup J., Allison S.P., Elia M., Vellas B., Plauth M., ESPEN guidelines for nutrition screening 2002, CLIN NUTR, 22, 4, pp. 415-421, (2003)
  • [9] Shi X., Shen Y., Yang J., Du W., Yang J., The relationship of the geriatric nutritional risk index to mortality and length of stay in elderly patients with acute respiratory failure: A retrospective cohort study, HEART LUNG, 50, 6, pp. 898-905, (2021)
  • [10] Bouillanne O., Morineau G., Dupont C., Coulombel I., Vincent J.P., Nicolis I., Benazeth S., Cynober L., Aussel C., Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients, AM J CLIN NUTR, 82, 4, pp. 777-783, (2005)
1234