Synthesis and Study of the Biological Activity of New Compounds Derived from 4-(5-Phenyl-1,3,4-oxadiazole-2-yl)aniline

被引：1

作者：

Alheety, K. A. ^{[1
]}

Jamel, N. M. ^{[1
]}

Abd-Al Hameed, W. M. ^{[2
]}

Al-Rawi, M. S. ^{[1
]}

Tomma, J. H. ^{[1
]}

机构：

[1] Univ Baghdad, Coll Educ Pure Sci Ibn Al Haitham, Dept Chem, Baghdad 10053, Iraq

[2] Univ Baghdad, Coll Agr Engn Sci, Baghdad 10070, Iraq

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 07期

关键词：

1,3,4-oxadiazole; Schiff bases; azetidin-2-one; N-acyl; biological activity; DERIVATIVES;

D O I：

10.1134/S1070428024070261

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of N-acyl derivatives (4a-4d) and Azetidin-2-one derivatives (5a, 5b) containing a 1,3,4-oxadiazole ring were prepared by sequence reactions. The new Schiff bases (3a-3d) used as starting materials were prepared via condensation of (4-(5-phenyl-1,3,4-oxadiazole-2yl)aniline) with four replaced aromatic dialdehyde (2a-2d). The newly synthesized Schiff bases (3a-3d) reacted with, acetyl chloride in the dry benzene to get new derivatives (4a-4d). While the second path was towards the formation of new Azetidin-2-one derivatives (5a, 5b) from cyclization reaction of the Schiff bases with chloroacetylchloride in dioxan and triethylamine at 0-5 degrees C. Synthesized compounds had been characterized by FT-IR and 1H NMR spectra in order to elucidate their structures. Finally, the resulting products were evaluated for it is efficacy measurements against two types of bacteria showed excellent to good efficacy antibacterial activity.

引用

页码：1342 / 1347

页数：6

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