CXCR4-targeted PET imaging in rheumatoid arthritis: a novel approach for monitoring disease activity and therapeutic response

被引：1
作者：
Han, Ya [1 ,2 ]
Cao, Shuo [1 ,2 ]
Liu, Jie [3 ]
Ding, Binbin [1 ,2 ]
Wang, Shijie [3 ]
Pan, Jihong [1 ,2 ]
Ge, Yongpeng [4 ]
Cheng, Kai [3 ]
Wang, Lin [1 ,2 ]
Ge, Luna [1 ,2 ]
机构：
[1] Shandong First Med Univ, Shandong Acad Med Sci, Biomed Sci Coll, Jinan, Peoples R China
[2] Shandong First Med Univ, Shandong Acad Med Sci, Key Lab Rare & Uncommon Dis Shandong Prov, NHC Key Lab Biotechnol Drugs,Shandong Med Biotechn, Jinan, Peoples R China
[3] Shandong First Med Univ, Shandong Canc Hosp & Inst, Shandong Acad Med Sci, Dept PET CT Ctr, Jinan 250117, Shandong, Peoples R China
[4] China Japan Friendship Hosp, Dept Rheumatol, Key Myositis Labs, Beijing, Peoples R China
来源：
EJNMMI RESEARCH | 2025年 / 15卷 / 01期
关键词：
CXCR4; PET imaging; Rheumatoid arthritis; Disease activity; CXCR4;
D O I：
10.1186/s13550-025-01203-z
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
BackgroundRheumatoid arthritis (RA) is a common chronic, inflammatory autoimmune disease, and early clinical diagnosis is crucial for its treatment. CXCR4 expression was characterized in arthritic mouse models and joints of RA patients, and [18 F]AIF-NOTA-QHA-04 specificity was assessed in non-malignant cells with elevated CXCR4 expression. This study explored the application of CXCR4-targeted PET probe [18 F]AIF-NOTA-QHA-04 in monitoring disease activity and therapeutic efficacy in RA. To this aim, the metabolic characteristics of [18 F]AIF-NOTA-QHA-04 and correlation of [18 F]AIF-NOTA-QHA-04 uptake with arthritis severity were evaluated by PET imaging in arthritic mice. [18 F]AIF-NOTA-QHA-04 potential in evaluating therapeutic efficacy was further investigated in arthritic mice following methotrexate (MTX) and etanercept (ETC) treatment.ResultsCXCR4 expression was significantly increased in the inflamed joints of collagen-induced arthritis (CIA) and collagen-antibody induced arthritic (CAIA) mice, and in synovial tissues of RA patients. [18 F]AIF-NOTA-QHA-04 showed high specificity for CXCR4, with increased probe uptake in arthritic joints that was strongly correlated with arthritis severity scores. PET imaging revealed that increased uptake of [18 F]AIF-NOTA-QHA-04 in arthritic joints paralleled disease activity, with uptake decreasing upon remission. Furthermore, [18 F]AIF-NOTA-QHA-04 PET imaging provided earlier and more sensitive assessments of the efficacy of MTX and ETC compared to traditional methods.ConclusionThe CXCR4-targeted PET probe [18 F]AIF-NOTA-QHA-04 is a promising tool for RA diagnosis and monitoring, with high specificity and sensitivity. The potential of this probe as a biomarker for disease activity and therapeutic response underscores its value in personalized medication strategies for the management of RA.
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页数：12
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