Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics

被引：2

作者：

Shou, Songting ^{[1
]}

Maolan, Ayidana ^{[1
]}

Zhang, Di ^{[1
]}

Jiang, Xiaochen ^{[1
]}

Liu, Fudong ^{[1
]}

Li, Yi ^{[1
]}

Zhang, Xiyuan ^{[1
]}

Geer, En ^{[1
]}

Pu, Zhenqing ^{[1
]}

Hua, Baojin ^{[1
]}

Guo, Qiujun ^{[1
]}

Zhang, Xing ^{[1
]}

Pang, Bo ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2025年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Telomeres; Telomere shortening; Cancer; TERT PROMOTER MUTATIONS; MESSENGER-RNA EXPRESSION; HUMAN BREAST-CANCER; CHRONIC MYELOID-LEUKEMIA; CELL LUNG-CANCER; QUADRUPLEX LIGAND RHPS4; STRUCTURE-BASED DESIGN; DNA-DAMAGE RESPONSES; REVERSE-TRANSCRIPTASE; PHASE-I;

D O I：

10.1186/s40164-025-00597-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomeres and telomerase play crucial roles in the initiation and progression of cancer. As biomarkers, they aid in distinguishing benign from malignant tissues. Despite the promising therapeutic potential of targeting telomeres and telomerase for therapy, translating this concept from the laboratory to the clinic remains challenging. Many candidate drugs remain in the experimental stage, with only a few advancing to clinical trials. This review explores the relationship between telomeres, telomerase, and cancer, synthesizing their roles as biomarkers and reviewing the outcomes of completed trials. We propose that changes in telomere length and telomerase activity can be used to stratify cancer stages. Furthermore, we suggest that differential expression of telomere and telomerase components at the subcellular level holds promise as a biomarker. From a therapeutic standpoint, combining telomerase-targeted therapies with drugs that mitigate the adverse effects of telomerase inhibition may offer a viable strategy.

引用

页数：47

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