Chemokine CXCL13-CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases

被引：7

作者：

Zheng, Kaige ^{[1
]}

Chen, Muyan ^{[1
]}

Xu, Xingjianyuan ^{[1
]}

Li, Peiyi ^{[1
]}

Yin, Chengyu ^{[1
]}

Wang, Jie ^{[2
]}

Liu, Boyi ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou, Peoples R China

[2] Zhejiang Univ, Sch Med, Second Affiliated, Dept Rehabil Tradit Chinese Med, Hangzhou, Peoples R China

来源：

CELLULAR & MOLECULAR BIOLOGY LETTERS | 2024年 / 29卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Chemokine; Neuroinflammation; Pain; Astrocyte; Neuron; CXCL13; COMPLEX REGIONAL PAIN; ANTERIOR CINGULATE CORTEX; CHRONIC POSTSURGICAL PAIN; TUMOR-NECROSIS-FACTOR; DORSAL-ROOT GANGLIA; NEUROPATHIC PAIN; ASTROCYTE ACTIVATION; NERVE LIGATION; MECHANISMS; MODEL;

D O I：

10.1186/s11658-024-00653-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and the health care system. However, the current treatments for chronic pain are usually insufficient and cause many unwanted side effects. Chemokine C-X-C motif ligand 13 (CXCL13), formerly recognized as a B cell chemokine, binds with the cognate receptor CXCR5, a G-protein-coupled receptor (GPCR), to participate in immune cell recruitments and immune modulations. Recent studies further demonstrated that CXCL13-CXCR5 signaling is implicated in chronic pain via promoting neuroimmune interaction and neuroinflammation in the sensory system. In addition, some latest work also pointed out the involvement of CXCL13-CXCR5 in the pathogenesis of certain neurological diseases, including ischemic stroke and amyotrophic lateral sclerosis. Therefore, we aim to outline the recent findings in regard to the involvement of CXCL13-CXCR5 signaling in chronic pain as well as certain neurological diseases, with the focus on how this chemokine signaling contributes to the pathogenesis of these neurological diseases via regulating neuroimmune interaction and neuroinflammation. Strategies that can specifically target CXCL13-CXCR5 signaling in distinct locations may provide new therapeutic options for these neurological diseases.

引用

页数：21