The transcription factor FOXQ1 in cancer

被引：0
作者：
Koch, Stefan [1 ,2 ]
机构：
[1] Linkoping Univ, Wallenberg Ctr Mol Med WCMM, Linkoping, Sweden
[2] Linkoping Univ, Dept Biomed & Clin Sci BKV, BKV MMV Plan 13,Lab 1, S-58185 Linkoping, Sweden
来源：
CANCER AND METASTASIS REVIEWS | 2025年 / 44卷 / 01期
关键词：
Forkhead box; Transcription factor; Metastasis; Gene regulation; Epithelial-to-mesenchymal transition; EPITHELIAL-MESENCHYMAL TRANSITION; FORKHEAD BOX Q1; HEPATOCELLULAR-CARCINOMA METASTASIS; COLORECTAL-CANCER; PANCREATIC-CANCER; UP-REGULATION; EMT; EXPRESSION; IDENTIFICATION; TARGET;
D O I：
10.1007/s10555-025-10240-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
FOXQ1 is a member of the large forkhead box (FOX) family of transcription factors that is involved in all aspects of mammalian development, physiology, and pathobiology. FOXQ1 has emerged as a major regulator of epithelial-to-mesenchymal transition and tumour metastasis in cancers, especially carcinomas of the digestive tract. Accordingly, FOXQ1 induction is recognised as an independent prognostic factor for worse overall survival in several types of cancer, including gastric and colorectal cancer. In this review article, I summarise new evidence on the role of FOXQ1 in cancer, with a focus on molecular mechanisms that control FOXQ1 levels and the regulation of FOXQ1 target genes. Unravelling the functions of FOXQ1 has the potential to facilitate the development of targeted treatments for metastatic cancers.
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页数：17
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  • [1] Unraveling the Role of FOXQ1 in Colorectal Cancer Metastasis
    Abba, Mohammed
    Patil, Nitin
    Rasheed, Kabeer
    Nelson, Laura D.
    Mudduluru, Giridhar
    Leupold, Joerg Hendrik
    Allgayer, Heike
    [J]. MOLECULAR CANCER RESEARCH, 2013, 11 (09) : 1017 - 1028
  • [2] Identification and functional characterization of transcriptional activators in human cells
    Alerasool, Nader
    Leng, He
    Lin, Zhen-Yuan
    Gingras, Anne-Claude
    Taipale, Mikko
    [J]. MOLECULAR CELL, 2022, 82 (03) : 677 - +
  • [3] FOXQ1 controls the induced differentiation of melanocytic cells
    Bagati, Archis
    Bianchi-Smiraglia, Anna
    Moparthy, Sudha
    Kolesnikova, Kateryna
    Fink, Emily E.
    Kolesnikova, Masha
    Roll, Matthew V.
    Jowdy, Peter
    Wolff, David W.
    Polechetti, Anthony
    Yun, Dong Hyun
    Lipchick, Brittany C.
    Paul, Leslie M.
    Wrazen, Brian
    Moparthy, Kalyana
    Mudambi, Shaila
    Morozevich, Galina E.
    Georgieva, Sofia G.
    Wang, Jianmin
    Shafirstein, Gal
    Liu, Song
    Kandel, Eugene S.
    Berman, Albert E.
    Box, Neil F.
    Paragh, Gyorgy
    Nikiforov, Mikhail A.
    [J]. CELL DEATH AND DIFFERENTIATION, 2018, 25 (06) : 1040 - 1049
  • [4] Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1
    Bagati, Archis
    Bianchi-Smiraglia, Anna
    Moparthy, Sudha
    Kolesnikova, Kateryna
    Fink, Emily E.
    Lipchick, Brittany C.
    Kolesnikova, Masha
    Jowdy, Peter
    Polechetti, Anthony
    Mahpour, Amin
    Ross, Jason
    Wawrzyniak, Joseph A.
    Yun, Dong Hyun
    Paragh, Gyorgy
    Kozlova, Nadezhda I.
    Berman, Albert E.
    Wang, Jianmin
    Liu, Song
    Nemeth, Michael J.
    Nikiforov, Mikhail A.
    [J]. CELL REPORTS, 2017, 20 (12): : 2820 - 2832
  • [5] EMT, MET, Plasticity, and Tumor Metastasis
    Bakir, Basil
    Chiarella, Anna M.
    Pitarresi, Jason R.
    Rustgi, Anil K.
    [J]. TRENDS IN CELL BIOLOGY, 2020, 30 (10) : 764 - 776
  • [6] Pioneer factors as master regulators of the epigenome and cell fate
    Balsalobre, Aurelio
    Drouin, Jacques
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2022, 23 (07) : 449 - 464
  • [7] Pancreatic Cancer Stem-like Cells Display Aggressive Behavior Mediated via Activation of FoxQ1
    Bao, Bin
    Azmi, Asfar S.
    Aboukameel, Amro
    Ahmad, Aamir
    Bolling-Fischer, Aliccia
    Sethi, Seema
    Ali, Shadan
    Li, Yiwei
    Kong, Dejuan
    Banerjee, Sanjeev
    Back, Jessica
    Sarkar, Fazlul H.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (21) : 14520 - 14533
  • [8] PROTAC targeted protein degraders: the past is prologue
    Bekes, Miklos
    Langley, David R.
    Crews, Craig M.
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2022, 21 (03) : 181 - 200
  • [9] Forkhead transcription factors: key players in health and disease
    Benayoun, Berenice A.
    Caburet, Sandrine
    Veitia, Reiner A.
    [J]. TRENDS IN GENETICS, 2011, 27 (06) : 224 - 232
  • [10] When the chains do not break: the role of USP10 in physiology and pathology
    Bhattacharya, Udayan
    Neizer-Ashun, Fiifi
    Mukherjee, Priyabrata
    Bhattacharya, Resham
    [J]. CELL DEATH & DISEASE, 2020, 11 (12)
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