Effect of an experimental pregabalin gel on dental sensitivity and color change after bleaching with 35% hydrogen peroxide: a randomized clinical trial

Objective This clinical study evaluated an experimental pregabalin (PG) gel in reducing dental sensitivity (DS) and color change after dental bleaching. Materials and methods Seventy-five volunteers were selected and randomized into three groups: GPG (10% pregabalin gel), GKF (5% potassium nitrate and 2% sodium fluoride), and GP (placebo gel). Prior to the bleaching treatment, GPG and GKF received applications of the respective desensitizing gels for 10 min. The GP group received an application of placebo gel, similar to the other groups. The bleaching was performed with 35% hydrogen peroxide in 3 sessions, with a 7-day interval between sessions. Post-bleaching DS was assessed using the visual analog scale (VAS) over 21 days of follow-up. Color Assessment (Delta E00, Delta WID, and Delta Eab) and luminosity (L) were measured at baseline (T0) and 7 days after the third session (T1). Friedman, Kruskal-Wallis, one-way ANOVA, and Tukey tests were used, with alpha = 5%. Results Intergroup analysis showed that on the 1st, 8th, and 15th days, DS was higher for GP (p < 0.006; p = 0.004; p < 0.001) and did not differ between GKF and GPG (p = 0.203; p = 0.178; p = 0.09). In the intragroup analysis, GP showed a significant increase in DS on the 15th day (p < 0.001). Conclusions The experimental 10% pregabalin gel reduced dental sensitivity and did not interfere with bleaching results.