Radiation-induced lung injury: from mechanism to prognosis and drug therapy

被引：1

作者：

Wang, Sheng ^{[2
]}

Xu, Duo ^{[1
]}

Xiao, Lingyan ^{[1
]}

Liu, Bo ^{[1
]}

Yuan, Xianglin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Hubei, Peoples R China

[2] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Dept Radiat Oncol,Jiangsu Canc Hosp, Nanjing 210000, Jiangsu, Peoples R China

来源：

RADIATION ONCOLOGY | 2025年 / 20卷 / 01期

关键词：

Radiation-induced lung injury; Target cells; Signaling pathways; Predictive models; Pharmacotherapy; INDUCED PULMONARY-FIBROSIS; PNEUMONITIS; CANCER; AUTOPHAGY; RADIOTHERAPY; INHIBITION; ACTIVATION;

D O I：

10.1186/s13014-025-02617-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation induced lung injury, known as the main complication of thoracic radiation, remains to be a major resistance to tumor treatment. Based on the recent studies on radiation-induced lung injury, this review collated the possible mechanisms at the level of target cells and key pathways, corresponding prognostic models including predictors, patient size, number of centers, radiotherapy technology, construction methods and accuracy, and pharmacotherapy including drugs, targets, therapeutic effects, impact on anti-tumor treatment and research types. The research priorities and limitations are summarized to provide a reference for the research and management of radiation-induced lung injury.

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页数：10

相关论文

共 128 条

[91] Emerging therapeutic opportunities for integrin inhibitors [J].

Slack, R. J. ;

Macdonald, S. J. F. ;

Roper, J. A. ;

Jenkins, R. G. ;

Hatley, R. J. D. .

NATURE REVIEWS DRUG DISCOVERY, 2022, 21 (01) :60-78

[92] Immunological markers that predict radiation toxicity [J].

Sprung, Carl N. ;

Forrester, Helen B. ;

Siva, Shankar ;

Martin, Olga A. .

CANCER LETTERS, 2015, 368 (02) :191-197

[93] Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].

Sung, Hyuna ;

Ferlay, Jacques ;

Siegel, Rebecca L. ;

Laversanne, Mathieu ;

Soerjomataram, Isabelle ;

Jemal, Ahmedin ;

Bray, Freddie .

CA-A CANCER JOURNAL FOR CLINICIANS, 2021, 71 (03) :209-249

[94] The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis [J].

Suresh, Karthik ;

Naidoo, Jarushka ;

Zhong, Qiong ;

Xiong, Ye ;

Mammen, Jennifer ;

de Flores, Marcia Villegas ;

Cappelli, Laura ;

Balaji, Aanika ;

Palmer, Tsvi ;

Forde, Patrick M. ;

Anagnostou, Valsamo ;

Ettinger, David S. ;

Marrone, Kristen A. ;

Kelly, Ronan J. ;

Hann, Christine L. ;

Levy, Benjamin ;

Feliciano, Josephine L. ;

Lin, Cheng-Ting ;

Feller-Kopman, David ;

Lerner, Andrew D. ;

Lee, Hans ;

Shafiq, Majid ;

Yarmus, Lonny ;

Lipson, Evan J. ;

Soloski, Mark ;

Brahmer, Julie R. ;

Danoff, Sonye K. ;

D'Alessio, Franco .

JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (10) :4305-4315

[95] Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities [J].

Tahir, Salahaldin A. ;

Gao, Jianjun ;

Miura, Yuji ;

Blando, Jorge ;

Tidwell, Rebecca S. S. ;

Zhao, Hao ;

Subudhi, Sumit K. ;

Tawbi, Hussein ;

Keung, Emily ;

Wargo, Jennifer ;

Allison, James P. ;

Sharma, Padmanee .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (44) :22246-22251

[96] Severe COPD Is Correlated With Mild Radiation Pneumonitis Following Stereotactic Body Radiotherapy [J].

Takeda, Atsuya ;

Kunieda, Etsuo ;

Ohashi, Toshio ;

Aoki, Yousuke ;

Oku, Yohei ;

Enomoto, Tatsuji ;

Nomura, Koichiro ;

Sugiura, Madoka .

CHEST, 2012, 141 (04) :858-866

[97] Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy [J].

Tang, Yang ;

Yang, Li ;

Qin, Wan ;

Yi, Min' Xiao ;

Liu, Bo ;

Yuan, Xiang'Lin .

RADIATION ONCOLOGY, 2020, 15 (01)

[98] Overcoming TGFβ-mediated immune evasion in cancer [J].

Tauriello, Daniele V. F. ;

Sancho, Elena ;

Batlle, Eduard .

NATURE REVIEWS CANCER, 2022, 22 (01) :25-44

[99] Radiation recall pneumonitis induced by PD-1/PD-L1 blockades: mechanisms and therapeutic implications [J].

Teng, Feifei ;

Li, Min ;

Yu, Jinming .

BMC MEDICINE, 2020, 18 (01)

[100] Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis [J].

Thi Hang Giang Phan ;

Paliogiannis, Panagiotis ;

Nasrallah, Gheyath K. ;

Giordo, Roberta ;

Eid, Ali Hussein ;

Fois, Alessandro Giuseppe ;

Zinellu, Angelo ;

Mangoni, Arduino Aleksander ;

Pintus, Gianfranco .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 78 (05) :2031-2057

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