Radiation-induced lung injury: from mechanism to prognosis and drug therapy

被引：1

作者：

Wang, Sheng ^{[2
]}

Xu, Duo ^{[1
]}

Xiao, Lingyan ^{[1
]}

Liu, Bo ^{[1
]}

Yuan, Xianglin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Oncol, Wuhan 430030, Hubei, Peoples R China

[2] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Dept Radiat Oncol,Jiangsu Canc Hosp, Nanjing 210000, Jiangsu, Peoples R China

来源：

RADIATION ONCOLOGY | 2025年 / 20卷 / 01期

关键词：

Radiation-induced lung injury; Target cells; Signaling pathways; Predictive models; Pharmacotherapy; INDUCED PULMONARY-FIBROSIS; PNEUMONITIS; CANCER; AUTOPHAGY; RADIOTHERAPY; INHIBITION; ACTIVATION;

D O I：

10.1186/s13014-025-02617-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation induced lung injury, known as the main complication of thoracic radiation, remains to be a major resistance to tumor treatment. Based on the recent studies on radiation-induced lung injury, this review collated the possible mechanisms at the level of target cells and key pathways, corresponding prognostic models including predictors, patient size, number of centers, radiotherapy technology, construction methods and accuracy, and pharmacotherapy including drugs, targets, therapeutic effects, impact on anti-tumor treatment and research types. The research priorities and limitations are summarized to provide a reference for the research and management of radiation-induced lung injury.

引用

页数：10

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