Revealing connectivity patterns of deep brain stimulation efficacy in Parkinson's disease

被引：0
作者：
Vytvarova, Eva [1 ,2 ]
Lamos, Martin [1 ,5 ]
Hlinka, Jaroslav [3 ,4 ]
Goldemundova, Sabina [1 ]
Rektor, Ivan [1 ,5 ]
Bockova, Martina [1 ,5 ]
机构：
[1] Masaryk Univ, Cent European Inst Technol CEITEC, Brain & Mind Res Program, Brno, Czech Republic
[2] Masaryk Univ, Fac Informat, Brno, Czech Republic
[3] Czech Acad Sci, Inst Comp Sci, Dept Complex Syst, Prague, Czech Republic
[4] Natl Inst Mental Hlth, Klecany, Czech Republic
[5] Masaryk Univ, St Annes Hosp, Sch Med, Dept Neurol 1, Brno, Czech Republic
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
Functional connectivity; EEG; Connectivity patterns; Subthalamic nucleus; Parkinson's disease; Deep brain stimulation; HUMAN SUBTHALAMIC NUCLEUS; OSCILLATORY ACTIVITY; BETA; EEG; IMPAIRMENT; ELECTROENCEPHALOGRAM; MULTICENTER; DOPAMINE; NETWORKS; TOOLBOX;
D O I：
10.1038/s41598-024-80630-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim of this work was to study the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on the subnetwork of subcortical and cortical motor regions and on the whole brain connectivity using the functional connectivity analysis in Parkinson's disease (PD). The high-density source space EEG was acquired and analyzed in 43 PD subjects in DBS on and DBS off stimulation states (off medication) during a cognitive-motor task. Increased high gamma band (50-100 Hz) connectivity within subcortical regions and between subcortical and cortical motor regions was significantly associated with the Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III improvement after DBS. Whole brain neural correlates of cognitive performance were also detected in the high gamma (50-100 Hz) band. A whole brain multifrequency connectivity profile was found to classify optimal and suboptimal responders to DBS with a positive predictive value of 0.77, negative predictive value of 0.55, specificity of 0.73, and sensitivity of 0.60. Specific connectivity patterns related to PD, motor symptoms improvement after DBS, and therapy responsiveness predictive connectivity profiles were uncovered.
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页数：12
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