Association of IL-1RAcP rs16865597 gene polymorphism with susceptibility to essential hypertension: a case-control study in the Chinese Han population

被引:0
作者
Wu, Fangqin [1 ]
Liu, Dongchen [2 ]
Xia, Xin [1 ]
Yang, Xinlei [3 ]
Huang, Suli [4 ]
Jiang, Xinghua [1 ]
LuLi [2 ,5 ]
机构
[1] Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, 1Minde Rd, Nanchang, Peoples R China
[2] Shantou Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Med Coll, Shantou, Peoples R China
[3] Nanchang Univ, Affiliated Hosp 2, Biobank Ctr, 1 MinDe Rd, Nanchang, Peoples R China
[4] Shenzhen Ctr Dis Control & Prevent, Dept Environm & Hlth, Shenzhen, Peoples R China
[5] Shantou Univ, Guangdong Prov Key Lab Infect Dis & Mol Immunopath, Med Coll, Shantou, Peoples R China
关键词
Essential hypertension; Interleukin-33; interleukin-1receptor associated protein; Genetic polymorphisms; rs16865597; CORONARY-HEART-DISEASE; SOLUBLE ST2; IL-33; INFLAMMATION; STRESS; AXIS;
D O I
10.1186/s12872-025-04629-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundThe IL-33/ST2 pathway plays a crucial role in the development of essential hypertension (EH). This study aimed to investigate the relationship between EH and genetic variations in this pathway in the Chinese Han population.MethodsA total of 1,151 EH patients and 1,135 healthy controls were included in the study. Sixteen single nucleotide polymorphisms (SNPs) in the interleukin-33 (IL-33) and interleukin-1receptor associated protein (IL-1RAcP) genes were genotyped using the Sequenom MassArray and TaqMan assays. Genotype and allele frequencies were compared between the EH patients and controls using logistic regression analysis.ResultsThe rs16865597 SNP in the IL-1RAcP gene was found to be associated with the risk of EH. Specifically, the presence of the C allele of rs16865597 was negatively correlated with EH susceptibility in both the additive model (P = 0.014, OR = 0.75, 95% CI = 0.59-0.94) and the recessive model (P = 0.011, OR = 0.72, 95% CI = 0.56-0.93). Additionally, rs16865597 was linked to a reduced risk of EH in specific subgroups, including males (OR add = 0.73, 95% CI = 0.56-0.94, P = 0.015), nonsmokers (OR add = 0.72, 95% CI = 0.54-0.96, P = 0.023), nondrinkers (OR add = 0.70, 95% CI = 0.53-0.93, P = 0.013), and individuals with low BMI (OR add = 0.69, 95% CI = 0.51-0.92, P = 0.013). Moreover, the C genotype of rs16865597 was strongly associated with higher interleukin-10 levels in vivo.ConclusionThe rs16865597 SNP is significantly associated with a reduced risk of EH in the Chinese Han population, potentially due to its role in immune regulation.
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页数:8
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共 27 条
[1]  
Agita A, 2017, ACTA MED INDONES, V49, P158
[2]   Elevated circulating sST2 associated with subclinical atherosclerosis in newly diagnosed primary hypertension [J].
Ates, Ihsan ;
Ozkayar, Nihal ;
Ates, Hale ;
Karakulak, Ugur Nadir ;
Kursun, Oguzhan ;
Topcuoglu, Canan ;
Inan, Bayram ;
Yilmaz, Nisbet .
HYPERTENSION RESEARCH, 2016, 39 (07) :513-518
[3]  
Butler Merlin G, 2010, J Med Liban, V58, P175
[4]   IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex [J].
Chackerian, Alissa A. ;
Oldham, Elizabeth R. ;
Murphy, Erin E. ;
Schmitz, Jochen ;
Pflanz, Stefan ;
Kastelein, Robert A. .
JOURNAL OF IMMUNOLOGY, 2007, 179 (04) :2551-2555
[5]   Distribution and Clinical Correlates of the Interleukin Receptor Family Member Soluble ST2 in the Framingham Heart Study [J].
Coglianese, Erin E. ;
Larson, Martin G. ;
Vasan, Ramachandran S. ;
Ho, Jennifer E. ;
Ghorbani, Anahita ;
McCabe, Elizabeth L. ;
Cheng, Susan ;
Fradley, Michael G. ;
Kretschman, Dana ;
Gao, Wei ;
O'Connor, George ;
Wang, Thomas J. ;
Januzzi, James L. .
CLINICAL CHEMISTRY, 2012, 58 (12) :1673-1681
[6]   The IL-33/ST2 axis: Role in health and disease [J].
De la Fuente, Marjorie ;
MacDonald, Thomas T. ;
Hermoso, Marcela A. .
CYTOKINE & GROWTH FACTOR REVIEWS, 2015, 26 (06) :615-623
[7]   Dysregulation of IL-33/ST2 signaling and myocardial periarteriolar fibrosis [J].
Garbern, Jessica C. ;
Williams, Jason ;
Kristl, Amy C. ;
Malick, Alyyah ;
Rachmin, Inbal ;
Gaet, Benjamin ;
Ahmed, Nafis ;
Vujic, Ana ;
Libby, Peter ;
Lee, Richard T. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2019, 128 :179-186
[8]  
Gauderman WJ., 2009, QUANTO 11 COMPUTER P
[9]   IL-33 (Interleukin 33)/sST2 (Soluble Suppression of Tumorigenicity 2) Axis in Hypertension and Heart Failure [J].
Ghali, Rana ;
Altara, Raffaele ;
Louch, William E. ;
Cataliotti, Alessandro ;
Mallat, Ziad ;
Kaplan, Abdullah ;
Zouein, Fouad A. ;
Booz, George W. .
HYPERTENSION, 2018, 72 (04) :818-828
[10]   Immune and inflammatory mechanisms in hypertension [J].
Guzik, Tomasz J. ;
Nosalski, Ryszard ;
Maffia, Pasquale ;
Drummond, Grant R. .
NATURE REVIEWS CARDIOLOGY, 2024, 21 (06) :417-429