Nickel-Catalyzed Cross-Electrophile Vinylation of α-Chloro Phosphonates

被引：1

作者：

Zou, Liang ^{[1
]}

Yang, Huimin ^{[1
]}

Xie, Tian ^{[1
]}

Wang, Li-Wei ^{[1
]}

Ye, Yang ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 21期

基金：

中国国家自然科学基金;

关键词：

ARYLATION; ACCESS;

D O I：

10.1021/acs.joc.4c01929

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a general and efficient Ni-catalyzed reductive cross-coupling reaction of substituted vinyl bromides and alpha-chloro phosphonates to access a set of alpha-vinyl phosphonates using zinc as the terminal reductant. This reaction exhibits broad substrate adaptability and good functional group tolerance, which allows to afford diverse compounds including structurally complex motifs from natural products and drugs. Furthermore, the practicality was certificated through the gram-scale and transformation experiments. The preliminary mechanistic investigations support a radical chain process. The potential to realize enantiomeric control makes it more valuable for further exploration.

引用

页码：15822 / 15833

页数：12

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