Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases

被引：0
作者：
Huang, Qiaolin [1 ]
Zhu, Xiaojian [1 ]
Zhang, Yicheng [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China
[2] Chinese Acad Med Sci, Minist Educ, NHC Key Lab Organ Transplantat, Key Lab Organ Transplantat,Key Lab Organ Transplan, Wuhan 430030, Hubei, Peoples R China
[3] Immunotherapy Res Ctr Hematol Dis Hubei Prov, Wuhan 430030, Hubei, Peoples R China
来源：
BIOMARKER RESEARCH | 2025年 / 13卷 / 01期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Engineering T cells; CAR T cell therapy; Autoimmune diseases; Fibrosis; Aging; CHIMERIC ANTIGEN RECEPTOR; HUMANIZED MOUSE MODEL; IN-VITRO; MULTIPLE-SCLEROSIS; VITILIGO LESIONS; TARGETED THERAPY; B-CELLS; EXPRESSION; POTENCY; REPLICATION;
D O I：
10.1186/s40364-025-00736-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. In this review, we highlight recent advances in the engineering of T cells in non-oncology areas, including autoimmune and inflammatory diseases, infections, fibrosis, hemophilia, and aging. Chimeric antigen receptor immunotherapy has shown good outcomes in non-oncology areas, but many challenges remain in improving its safety and efficacy and and expanding its application to the treatment of non-oncological diseases.
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页数：22
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共 197 条
  • [91] Liu L., 2020, J Qiqihar Med Univ, V41, P2855
  • [92] Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity
    Liu, Li
    Patel, Bhavik
    Ghanem, Mustafa H.
    Bundoc, Virgilio
    Zheng, Zhili
    Morgan, Richard A.
    Rosenberg, Steven A.
    Dey, Barna
    Berger, Edward A.
    [J]. JOURNAL OF VIROLOGY, 2015, 89 (13) : 6685 - 6694
  • [93] CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    Liu, Weihong
    Putnam, Amy L.
    Xu-yu, Zhou
    Szot, Gregory L.
    Lee, Michael R.
    Zhu, Shirley
    Gottlieb, Peter A.
    Kapranov, Philipp
    Gingeras, Thomas R.
    Fazekas de St Groth, Barbara
    Clayberger, Carol
    Soper, David M.
    Ziegler, Steven F.
    Bluestone, Jeffrey A.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (07) : 1701 - 1711
  • [94] Lu L., 2019, J Pract Liver Dis, V22, P793
  • [95] Idiopathic inflammatory myopathies
    Lundberg, Ingrid E.
    Fujimoto, Manabu
    Vencovsky, Jiri
    Aggarwal, Rohit
    Holmqvist, Marie
    Christopher-Stine, Lisa
    Mammen, Andrew L.
    Miller, Frederick W.
    [J]. NATURE REVIEWS DISEASE PRIMERS, 2021, 7 (01)
  • [96] Ma M, 2020, bioRxiv
  • [97] Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
    MacDonald, Katherine G.
    Hoeppli, Romy E.
    Huang, Qing
    Gillies, Jana
    Luciani, Dan S.
    Orban, Paul C.
    Broady, Raewyn
    Levings, Megan K.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (04) : 1413 - 1424
  • [98] CD19 CAR T cell therapy effective for systemic lupus erythematosus
    Gelfand, J.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (01) : 4 - 4
  • [99] Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    Magliozzi, Roberta
    Howell, Owain
    Vora, Abhilash
    Serafini, Barbara
    Nicholas, Richard
    Puopolo, Maria
    Reynolds, Richard
    Aloisi, Francesca
    [J]. BRAIN, 2007, 130 : 1089 - 1104
  • [100] Tumor Antigen Escape from CAR T-cell Therapy
    Majzner, Robbie G.
    Mackall, Crystal L.
    [J]. CANCER DISCOVERY, 2018, 8 (10) : 1219 - 1226
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