Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases

被引：0
作者：
Huang, Qiaolin [1 ]
Zhu, Xiaojian [1 ]
Zhang, Yicheng [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China
[2] Chinese Acad Med Sci, Minist Educ, NHC Key Lab Organ Transplantat, Key Lab Organ Transplantat,Key Lab Organ Transplan, Wuhan 430030, Hubei, Peoples R China
[3] Immunotherapy Res Ctr Hematol Dis Hubei Prov, Wuhan 430030, Hubei, Peoples R China
来源：
BIOMARKER RESEARCH | 2025年 / 13卷 / 01期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Engineering T cells; CAR T cell therapy; Autoimmune diseases; Fibrosis; Aging; CHIMERIC ANTIGEN RECEPTOR; HUMANIZED MOUSE MODEL; IN-VITRO; MULTIPLE-SCLEROSIS; VITILIGO LESIONS; TARGETED THERAPY; B-CELLS; EXPRESSION; POTENCY; REPLICATION;
D O I：
10.1186/s40364-025-00736-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. In this review, we highlight recent advances in the engineering of T cells in non-oncology areas, including autoimmune and inflammatory diseases, infections, fibrosis, hemophilia, and aging. Chimeric antigen receptor immunotherapy has shown good outcomes in non-oncology areas, but many challenges remain in improving its safety and efficacy and and expanding its application to the treatment of non-oncological diseases.
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页数：22
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