Surgical vs. non-surgical management of cervical spine fractures associated with ankylosing spinal disorders: a matched retrospective comparison assessing mortality

被引：0
作者：
Akerstedt, Josefin [1 ]
Buwaider, Ali [2 ]
El-Hajj, Victor Gabriel [2 ]
Wanman, Johan [1 ]
Frisk, Henrik [2 ]
Blixt, Simon [3 ]
Macdowall, Anna [3 ]
Edstrom, Erik [2 ,4 ]
Elmi-Terander, Adrian [2 ,3 ,4 ]
Charalampidis, Anastasios [5 ,6 ]
机构：
[1] Umea Univ, Dept Diagnost & Intervent, Umea, Sweden
[2] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
[3] Uppsala Acad Hosp, Dept Surg Sci, Uppsala, Sweden
[4] Lowenstromska Hosp, Capio Spine Ctr Stockholm Spine Ctr, Upplands Vasby, Sweden
[5] Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden
[6] Karolinska Univ Hosp, Dept Reconstruct Orthoped, Stockholm, Sweden
来源：
BMC MUSCULOSKELETAL DISORDERS | 2025年 / 26卷 / 01期
关键词：
Ankylosing spondylitis; Diffuse idiopathic skeletal hyperostosis; Cervical spinal fracture; Surgical treatment; Non-surgical treatment; Mortality; SPONDYLITIS; INJURY; DISEASE;
D O I：
10.1186/s12891-025-08437-x
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Background Ankylosing spinal disorders (ASD) increase the risk of unstable cervical spine fractures, posing a significant mortality risk. Surgery is recommended for patients with neurological deficits, but the effectiveness of non-surgical treatment in those without deficits remains unclear. This study aimed to compare survival rates between surgical and non-surgical treatments of ASD-related cervical fractures in a matched cohort. Methods The study analyzed data from the Swedish Fracture Registry (SFR) on adult patients treated for ASD-related cervical spine fractures between January 2015 and December 2021. Preoperative variables included age, sex, trauma type, neurological function, fracture morphology, and treatment method. Propensity score matching was conducted to compare outcomes between treatment groups, ensuring balanced comparison groups regarding age, sex, type of trauma, time from injury to admission, fracture type, level of injury, and neurological function. Results In total, 357 adult patients with ASD-related cervical spine fractures were analyzed. Among them, 186 were treated surgically and 171 non-surgically. Treatment failure and conversion so surgical treatment was seen in 3.4% of the non-surgically treated patients. Most patients were male (80%), with a median age of 75 years. Fractures were mainly caused by low-energy trauma (69%). Most patients (92%) were ambulatory (Frankel grade D or E). In the unmatched analysis, surgically treated patients had significantly lower 1-year mortality rates (13% vs. 22%; p < 0.001), but after matching, there were no longer any difference between the two groups (16% vs. 22%; p = 0.44). These findings were also validated on Kaplan-Meier analysis. Multivariable logistic regression analysis identified high age as the only predictor for 30-day mortality (OR 1.14 [95% CI 1.09-1.22], p < 0.001). Conclusion Following propensity score matching, surgical and conservative management result in similar mortality outcomes for neurologically intact patients with ASD fractures. Age, rather than treatment approach, emerged as a stronger predictor of overall mortality. Nonetheless, treatment decisions should also consider other clinical outcomes beyond mortality, emphasizing the need for an individualized approach until more robust evidence is available.
引用
收藏
页数：10
相关论文
共 24 条
  • [1] Hartmann S., Tschugg A., Wipplinger C., Thome C., Analysis of the Literature on Cervical Spine Fractures in Ankylosing Spinal Disorders, Global Spine Journal, 7, 5, pp. 469-481, (2017)
  • [2] Lukasiewicz A.M., Bohl D.D., Varthi A.G., Et al., Spinal Fracture in Patients With Ankylosing Spondylitis: Cohort Definition, Distribution of Injuries, and Hospital Outcomes, Spine (Philadelphia, Pa 1976), 41, 3, pp. 191-196, (2016)
  • [3] Westerveld L.A., Verlaan J.J., Oner F.C., Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications, Eur Spine J, 18, 2, pp. 145-156, (2009)
  • [4] Reveille J.D., Epidemiology of spondyloarthritis in North America, Am J Med Sci, 341, 4, pp. 284-286, (2011)
  • [5] Hiyama A., Katoh H., Sakai D., Sato M., Tanaka M., Watanabe M., Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) assessed with whole-spine computed tomography in 1479 subjects, BMC musculoskeletal disorders, 19, 1, (2018)
  • [6] Rustagi T.M.D., Drazin D.M.D.M.A., Oner C.M.D.P., Et al., Fractures in Spinal Ankylosing Disorders: A Narrative Review of Disease and Injury Types, Treatment Techniques, and Outcomes, JOrthop Trauma, 31, 4, pp. S57-S74, (2017)
  • [7] Thumbikat P., Hariharan R.P., Ravichandran G., McClelland M.R., Mathew K.M., Spinal cord injury in patients with ankylosing spondylitis: a 10-year review, Spine (Phila Pa 1976), 32, 26, pp. 2989-2995, (2007)
  • [8] Tetzlaff J.E., Yoon H.J., Bell G., Massive bleeding during spine surgery in a patient with ankylosing spondylitis, Can J Anaesth, 45, 9, pp. 903-906, (1998)
  • [9] Werner B.C., Samartzis D., Shen F.H., Spinal Fractures in Patients With Ankylosing Spondylitis: Etiology, Diagnosis, and Management, J Am Acad Orthop Surg, 24, 4, pp. 241-249, (2016)
  • [10] Robinson Y., Willander J., Olerud C., Surgical Stabilization Improves Survival of Spinal Fractures Related to Ankylosing Spondylitis, Spine (Phila Pa 1976), 40, 21, pp. 1697-1702, (2015)
123