Review and Future Perspectives of Stimuli-Responsive Bridged Polysilsesquioxanes in Controlled Release Applications

被引：2

作者：

Zhang, Xin ^{[1
]}

Zhang, Han ^{[2
]}

Liu, Xiaonan ^{[1
]}

Wang, Jiao ^{[2
]}

Li, Shifeng ^{[2
]}

Gao, Peng ^{[1
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Inst Pharmaceut Res, Shandong Key Lab Digital Tradit Chinese Med, Jinan 250355, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Dept Pharm, Jinan 250355, Peoples R China

来源：

POLYMERS | 2024年 / 16卷 / 22期

基金：

中国国家自然科学基金;

关键词：

stimuli-responsive; bridged polysilsesquioxanes; organosilicon; controlled release; targeted therapeutics; MESOPOROUS ORGANOSILICA NANOPARTICLES; DRUG-DELIVERY; SILSESQUIOXANE NANOPARTICLES; SILICA NANOPARTICLES; FRAMEWORK; SYSTEM; BIODEGRADABILITY; MICROPARTICLES; NANOMATERIALS; PLATFORMS;

D O I：

10.3390/polym16223163

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Bridged polysilsesquioxanes (BPSs) are emerging biomaterials composed of synergistic inorganic and organic components. These materials have been investigated as ideal carriers for therapeutic and diagnostic systems for their favorable properties, including excellent biocompatibility, physiological inertia, tunable size and morphology, and their extensive design flexibility of functional organic groups to satisfy diverse application requirements. Stimuli-responsive BPSs can be activated by both endogenous and exogenous stimuli, offering a precise, safe, and effective platform for the controlled release of various targeted therapeutics. This review aims to provide a comprehensive overview of stimuli-responsive BPSs, focusing on their synthetic strategies, biocompatibility, and biodegradability, while critically assessing their capabilities for controlled release in response to specific stimuli. Furthermore, practical suggestions and future perspectives for the design and development of BPSs are presented. This review highlights the significant role of stimuli-responsive BPSs in advancing biomedical research.

引用

页数：40

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