Effect of maternal exposure to antibiotics during pregnancy on the neonatal intestinal microbiome and health

被引:0
|
作者
Miyoshi, Jun [1 ]
Hisamatsu, Tadakazu [1 ]
机构
[1] Kyorin Univ, Sch Med, Dept Gastroenterol & Hepatol, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan
关键词
Intestinal microbiome; Antibiotics; Prenatal exposure; Dysbiosis; Health in offspring; HUMAN GUT MICROBIOME; INTRAPARTUM ANTIBIOTICS; BODY SITES; COLITIS; INFANTS; DISEASE; ONSET; RISK; TRANSMISSION; ASSOCIATION;
D O I
10.1007/s12328-024-02088-6
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Antibiotics are widely used during pregnancy. Recent epidemiological studies suggest that maternal exposure to antibiotics during pregnancy is associated with increased risks of various diseases in offspring; host-microbiome interactions are considered to be involved in pathogenesis, as antibiotic-induced perturbations (dysbiosis) of the maternal microbiome can be transmitted to offspring. We reviewed the current status of antibiotic usage during pregnancy, transmission of maternal antibiotic-induced dysbiosis to offspring, and several diseases in offspring reported to be associated with maternal antibiotic exposure. Antibiotics must be properly used when necessary. While the adverse effect of maternal antibiotic exposure during pregnancy on the health of offspring has been demonstrated by several studies, more robust clinical evidence is necessary to define the best practice for antibiotic use during pregnancy. Epidemiologic studies have limitations in establishing causal links beyond associations; animal studies provide benefits in examining these links, however, microbiomes, gestation courses, and aging vary between host species. Understanding the underlying mechanisms of epidemiologic findings as well as the healthy microbiome during pregnancy and early life in humans would contribute to developing future microbial interventions for restoring antibiotic-induced dysbiosis during pregnancy.
引用
收藏
页码:1 / 10
页数:10
相关论文
共 50 条
  • [1] The impact of maternal exposure to antibiotics on the development of child gut microbiome
    Miyoshi, Jun
    Hisamatsu, Tadakazu
    IMMUNOLOGICAL MEDICINE, 2022, 45 (02) : 63 - 68
  • [2] Early Colonization of the Intestinal Microbiome of Neonatal Piglets Is Influenced by the Maternal Microbiome
    Lim, Jin-A
    Cha, Jihye
    Choi, Soyoung
    Kim, Jae-Hwan
    Kim, Dahye
    ANIMALS, 2023, 13 (21):
  • [3] Urinary tetracycline antibiotics exposure during pregnancy and maternal thyroid hormone parameters: A repeated measures study
    Geng, Menglong
    Gao, Hui
    Wang, Baolin
    Huang, Kun
    Wu, Xiaoyan
    Liang, Chunmei
    Yan, Shuangqin
    Han, Yan
    Ding, Peng
    Wang, Wei
    Wang, Sheng
    Zhu, Peng
    Liu, Kaiyong
    Cao, Yunxia
    Tao, Fangbiao
    SCIENCE OF THE TOTAL ENVIRONMENT, 2022, 838
  • [4] MATERNAL PASSIVE SMOKING DURING PREGNANCY AND NEONATAL HEALTH
    Wdowiak, Artur
    Wiktor, Henryk
    Wdowiak, Leszek
    ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE, 2009, 16 (02) : 309 - 312
  • [5] Birth mode-dependent association between pre-pregnancy maternal weight status and the neonatal intestinal microbiome
    Mueller, Noel T.
    Shin, Hakdong
    Pizoni, Aline
    Werlang, Isabel C.
    Matte, Ursula
    Goldani, Marcelo Z.
    Goldani, Helena A. S.
    Dominguez-Bello, Maria Gloria
    SCIENTIFIC REPORTS, 2016, 6
  • [6] THE MATERNAL GUT MICROBIOME DURING PREGNANCY
    Edwards, Sara M.
    Cunningham, Solveig A.
    Dunlop, Anne L.
    Corwin, Elizabeth J.
    MCN-THE AMERICAN JOURNAL OF MATERNAL-CHILD NURSING, 2017, 42 (06) : 310 - 316
  • [7] Effect of Depressive Disorders and Their Pharmacological Treatment during Pregnancy on Maternal and Neonatal Outcome
    Parpinel, Giulia
    Rosso, Gianluca
    Galante, Arianna
    Germano, Chiara
    Aragno, Elena
    Girlando, Flavia
    Messina, Alessandro
    Laudani, Maria Elena
    Rolfo, Alessandro
    Attini, Rossella
    Revelli, Alberto
    Maina, Giuseppe
    Masturzo, Bianca
    JOURNAL OF CLINICAL MEDICINE, 2022, 11 (06)
  • [8] Adverse Effects of Black Carbon (BC) Exposure during Pregnancy on Maternal and Fetal Health: A Contemporary Review
    Goriainova, Viktoriia
    Awada, Christina
    Opoku, Florence
    Zelikoff, Judith T.
    TOXICS, 2022, 10 (12)
  • [9] Exposure to antibiotics during pregnancy alters offspring outcomes
    Qu, Wenhao
    Liu, Linsheng
    Miao, Liyan
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021, 17 (10) : 1165 - 1174
  • [10] Phosphatidylethanol in Maternal or Neonatal Blood to Detect Alcohol Exposure during Pregnancy: A Systematic Review
    Franceschetto, Lisa
    Perilli, Matteo
    Cinquetti, Alessandro
    Giraudo, Chiara
    Gardi, Mario
    Cecchetto, Giovanni
    Viel, Guido
    LIFE-BASEL, 2022, 12 (10):