Thermodynamic study of anhydrous and hydrated quercetin

Solid-state anhydrous (QA) and hydrated quercetins (QH) were studied by using combustion calorimetry and thermal analysis-simultaneous thermogravimetry (TG) coupled with differential scanning calorimetry (DSC) methods. The enthalpies of formation were derived employing the experimental heat of combustion for the studied compounds. The obtained data are compared with estimated values using group additivity and quantum calculations. The correlation between experimental and calculated values is discussed considering the number and strength of intermolecular hydrogen bonds. From DSC experiments, the temperature ranges of dehydration followed by melting-decomposition were established.Graphical abstractThe present study consists in bringing contributions to the completion of thermochemical data banks regarding the important role played by quercetin in the living organisms. The values of the thermodynamic quantities, which characterize the biochemical reactions, are put in correspondence with the biological activity of quercetin.Synopsis The present study consists in bringing contributions to the completion of thermochemical data banks regarding the important role played by quercetin in the living organisms. The values of the thermodynamic quantities, which characterize the biochemical reactions, are put in correspondence with the biological activity of quercetin.Graphical abstractThe present study consists in bringing contributions to the completion of thermochemical data banks regarding the important role played by quercetin in the living organisms. The values of the thermodynamic quantities, which characterize the biochemical reactions, are put in correspondence with the biological activity of quercetin.Synopsis The present study consists in bringing contributions to the completion of thermochemical data banks regarding the important role played by quercetin in the living organisms. The values of the thermodynamic quantities, which characterize the biochemical reactions, are put in correspondence with the biological activity of quercetin.