Exosomal Manf originated from endothelium regulated osteoclast differentiation by down-regulating NF-κB signaling pathway

被引:0
|
作者
Zhilong Pi [1 ]
You Wu [2 ]
Xinyu Wang [2 ]
Pingyue Li [2 ]
Renkai Wang [2 ]
机构
[1] Guangzhou University of Chinese Medicine,
[2] Guangdong Key Lab of Orthopaedic Technology and Implant Materials,undefined
[3] Key Laboratory of Trauma and Tissue Repair of Tropical Area of PLA,undefined
[4] Hospital of Orthopaedics,undefined
[5] General Hospital of Southern Theater Command of PLA,undefined
关键词
Endothelium; Exosome; Osteoclast; NF-κB; Manf;
D O I
10.1186/s13018-025-05671-w
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Gastrodin ameliorates atherosclerosis by inhibiting foam cells formation and inflammation through down-regulating NF-κB pathway
    Xue, Xiaofei
    Li, Fulei
    Xu, Mengke
    Chen, Bowen
    Zhao, Yanyan
    Wang, Mengyu
    Li, Ling
    NUTRITION & METABOLISM, 2023, 20 (01)
  • [22] Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK–NF-κB signaling pathway
    Gong-Rak Lee
    Soo Hwa Jang
    Chang Jae Kim
    Ah-Ram Kim
    Dong-Joon Yoon
    Neung-Hwa Park
    In-Seob Han
    Clinical & Experimental Metastasis, 2014, 31 : 897 - 907
  • [23] Bisphenol A and estradiol impede myoblast differentiation through down-regulating Akt signaling pathway
    Go, Ga-Yeon
    Lee, Sang-Jin
    Jo, Ayoung
    Lee, Jae-Rin
    Kang, Jong-Sun
    Yang, Mihi
    Bae, Gyu-Un
    TOXICOLOGY LETTERS, 2018, 292 : 12 - 19
  • [24] Inhibition of Osteoclast Differentiation by Carotenoid Derivatives through Inhibition of the NF-κB Pathway
    Odes-Barth, Shlomit
    Khanin, Marina
    Linnewiel-Hermoni, Karin
    Miller, Yifat
    Abramov, Karina
    Levy, Joseph
    Sharoni, Yoav
    ANTIOXIDANTS, 2020, 9 (11) : 1 - 16
  • [25] Plastrum testudinis extract suppresses osteoclast differentiation via the NF-κB signaling pathway and ameliorates senile osteoporosis
    Chen, Honglin
    Shen, Gengyang
    Shang, Qi
    Zhang, Peng
    Yu, Die
    Yu, Xiang
    Zhang, Zhida
    Zhao, Wenhua
    Wu, Zixian
    Tang, Fuyu
    Liang, De
    Jiang, Xiaobing
    Ren, Hui
    JOURNAL OF ETHNOPHARMACOLOGY, 2021, 276
  • [26] Hypoxia Promotes Osteoclast Differentiation by Weakening USP18-Mediated Suppression on the NF-κB Signaling Pathway
    Fan, Xiaoxia
    Li, Botong
    Chai, Shengjun
    Zhang, Rong
    Cai, Chunmei
    Ge, Rili
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (01)
  • [27] Inhibition of VCP modulates NF-?B signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation
    Wei, Rongfang
    Cao, Yuhao
    Wu, Hongjie
    Liu, Xin
    Jiang, Mingmei
    Luo, Xian
    Deng, Zhendong
    Wang, Ze
    Ke, Mengying
    Zhu, Yongqiang
    Chen, Siqing
    Gu, Chunyan
    Yang, Ye
    AGING-US, 2023, 15 (16): : 8220 - 8236
  • [28] Cucurbitacin E suppresses cytokine expression in human Jurkat T cells through down-regulating the NF-κB signaling
    Wang, Lixian
    Li, Chenguang
    Lin, Qiuru
    Zhang, Xiaoyu
    Pan, Hao
    Xu, Lihui
    Shi, Zijian
    Ouyang, Dongyun
    He, Xianhui
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2015, 47 (06) : 459 - 465
  • [29] Polyphyllin E Inhibits Proliferation, Migration and Invasion of Ovarian Cancer Cells by Down-Regulating the AKT/NF-κB Pathway
    Liu, Yinglei
    Cao, Yang
    Kai, Haili
    Han, Yuwen
    Huang, Menghui
    Gao, Liusijie
    Qiao, Haifeng
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2022, 45 (05) : 561 - 568
  • [30] Osthole protects sepsis-induced acute kidney injury via down-regulating NF-κB signal pathway
    Yu, Chen
    Li, Peng
    Qi, Dong
    Wang, Lei
    Qu, Hong-lin
    Zhang, Yue-juan
    Wang, Xue-kai
    Fan, Hua-Ying
    ONCOTARGET, 2017, 8 (03) : 4796 - 4813