Epidemiology of idiopathic pulmonary fibrosis in central and Western Pennsylvania

被引:0
作者
Linkov, Faina [1 ]
Chang, Yue-Fang [2 ]
Ramanan, Harshitha [1 ]
Morgan, Richard S. [6 ]
Mctigue, Kathleen M. [3 ]
Dimmock, Anne E. F. [4 ]
Bascom, Rebecca [4 ]
Kass, Daniel J. [5 ]
机构
[1] Duquesne Univ, John G Rangos Sr Sch Hlth Sci, Dept Hlth Exercise & Appl Sci, Pittsburgh, PA 15282 USA
[2] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA
[4] Penn State Coll Med, Penn State Milton S Hershey Med Ctr, Hershey, PA USA
[5] Univ Pittsburgh, Dorothy P & Richard P Simmons Ctr Interstitial Lun, Pittsburgh, PA USA
[6] Univ Pittsburgh, Dept Biomed Informat, Pittsburgh, PA USA
关键词
Epidemiology; Interstitial lung disease; CAPTURE-RECAPTURE METHODS; PREVALENCE; MORTALITY; POPULATION; UPDATE; MUTATIONS; DIAGNOSIS; PROMOTER; ADULTS; MUC5B;
D O I
10.1186/s12931-025-03164-2
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background/rationaleIdiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive disease of unknown origin. Establishing the epidemiology of IPF has been challenging due to diagnostic complexity, poor survival, low prevalence, and heterogeneity of ascertainment methodologies.ObjectivesThis research aimed to estimate the rates of IPF in central and western Pennsylvania and to pilot the use of capture recapture (CR) methods to estimate the disease incidence.MethodsWe identified adults >= 30 years old diagnosed with IPF (by ICD-9/10 coding) between 2013 to 2021 from two health systems (UPMC Health System and Penn State Health) participating in the PaTH Clinical Research Network. We extracted information on patients' sex, race, date of birth and 3-digit zip code from electronic health records (EHR). Incidence rate of IPF among Pennsylvania residents was calculated using three case definitions (broad and two restricted) and piloted the use of CR in estimating IPF incidence.ResultsIPF incidence rates were 8.42, 6.95 and 4.4 per 100,000 person-years for the unrestricted (n = 3148), partially restricted (n = 2598) and fully restricted (n = 1661) samples, respectively. Low case overlap between two sites resulted in a highly inflated estimate of IPF incidence, using the CR methodology.ConclusionsThe rate of IPF in central and western Pennsylvania was similar to previously published statistics. The application of CR to IPF epidemiology could be further investigated in health systems with greater overlap of patients utilizing more than one system.
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页数:10
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