Commentary on "Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth"

被引：0

作者：

Raitoharju, Emma ^{[1
,2
]}

Marttila, Saara ^{[1
,3
]}

机构：

[1] Tampere Univ, Fac Med & Hlth Technol, Mol Epidemiol MOLE, Tampere, Finland

[2] Fimlab Labs, Tampere, Finland

[3] Tampere Univ Hosp, Wellbeing Serv Cty Pirkanmaa, Tampere, Finland

来源：

MOLECULAR CANCER | 2025年 / 24卷 / 01期

基金：

芬兰科学院;

关键词：

nc886; VTRNA2-1; Paediatric leukaemia; Epigenetics; DNA methylation; Imprinting; BREAST;

D O I：

10.1186/s12943-024-02220-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

VTRNA2-1 is a polymorphically imprinted locus. The proportion of individuals with a maternally imprinted VTRNA2-1 locus is consistently approximately 75% in populations of European origin, with the remaining circa 25% having a non-methylated VTRNA2-1 locus. Recently, VTRNA2-1 hypermethylation at birth was suggested to be a precursor of paediatric acute lymphoblastic leukaemia with biomarker potential. The results presented by Ghantous et al. [1] allow for an alternative interpretation to what the authors discussed, and we argue that the observed methylation difference at birth is due to an uneven distribution of imprinted and non-methylated individuals among the cases and controls, with all individuals presenting normative physiological VTRNA2-1 methylation levels. In addition, the notable interindividual variation arising from the polymorphic imprinting in VTRNA2-1 methylation levels calls into question the validity of VTRNA2-1 methylation as a biomarker.

引用

页数：4

共 15 条

[1] NCBI GEO: archive for functional genomics data sets-update [J].

Barrett, Tanya ;

Wilhite, Stephen E. ;

Ledoux, Pierre ;

Evangelista, Carlos ;

Kim, Irene F. ;

Tomashevsky, Maxim ;

Marshall, Kimberly A. ;

Phillippy, Katherine H. ;

Sherman, Patti M. ;

Holko, Michelle ;

Yefanov, Andrey ;

Lee, Hyeseung ;

Zhang, Naigong ;

Robertson, Cynthia L. ;

Serova, Nadezhda ;

Davis, Sean ;

Soboleva, Alexandra .

NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D991-D995

[2] Integration of High-Resolution Methylome and Transcriptome Analyses to Dissect Epigenomic Changes in Childhood Acute Lymphoblastic Leukemia [J].

Busche, Stephan ;

Ge, Bing ;

Vidal, Ramon ;

Spinella, Jean-Francois ;

Saillour, Virginie ;

Richer, Chantal ;

Healy, Jasmine ;

Chen, Shu-Huang ;

Droit, Arnaud ;

Sinnett, Daniel ;

Pastinen, Tomi .

CANCER RESEARCH, 2013, 73 (14) :4323-4336

[3] Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886) [J].

Carpenter, Brittany L. ;

Remba, Tanaka K. ;

Thomas, Stacey L. ;

Madaj, Zachary ;

Brink, Lucy ;

Tiedemann, Rochelle L. ;

Odendaal, Hein J. ;

Jones, Peter A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (12)

[4] Heritable methylation marks associated with breast and prostate cancer risk [J].

Dugue, Pierre-Antoine ;

Dowty, James G. ;

Joo, Jihoon E. ;

Wong, Ee M. ;

Makalic, Enes ;

Schmidt, Daniel F. ;

English, Dallas R. ;

Hopper, John L. ;

Pedersen, John ;

Severi, Gianluca ;

MacInnis, Robert J. ;

Milne, Roger L. ;

Giles, Graham G. ;

Southey, Melissa C. .

PROSTATE, 2018, 78 (13) :962-969

[5]

FDA-NIH Biomarker Working Group, 2016, BEST BIOM ENDPOINTS

[6]

Fort Rafael Sebastian, 2021, F1000Res, V10, P182, DOI 10.12688/f1000research.28510.1

[7] Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth [J].

Ghantous, Akram ;

Nussle, Semira Gonseth ;

Nassar, Farah J. ;

Spitz, Natalia ;

Novoloaca, Alexei ;

Krali, Olga ;

Nickels, Eric ;

Cahais, Vincent ;

Cuenin, Cyrille ;

Roy, Ritu ;

Li, Shaobo ;

Caron, Maxime ;

Lam, Dilys ;

Fransquet, Peter Daniel ;

Casement, John ;

Strathdee, Gordon ;

Pearce, Mark S. ;

Hansen, Helen M. ;

Lee, Hwi-Ho ;

Lee, Yong Sun ;

de Smith, Adam J. ;

Sinnett, Daniel ;

Haberg, Siri Eldevik ;

McKay, Jill A. ;

Nordlund, Jessica ;

Magnus, Per ;

Dwyer, Terence ;

Saffery, Richard ;

Wiemels, Joseph Leo ;

Munthe-Kaas, Monica Cheng ;

Herceg, Zdenko .

MOLECULAR CANCER, 2024, 23 (01)

[8] Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins [J].

Hannon, Eilis ;

Knox, Olivia ;

Sugden, Karen ;

Burrage, Joe ;

Wong, Chloe C. Y. ;

Belsky, Daniel W. ;

Corcoran, David L. ;

Arseneault, Louise ;

Moffitt, Terrie E. ;

Caspi, Avshalom ;

Mill, Jonathan .

PLOS GENETICS, 2018, 14 (08)

[9]

Lee YJ, 2024, ETHNIC HEALTH, V29, P523, DOI [10.1080/13557858.2024.2337620, 10.1080/17501911.2024.2415278]

[10] Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues [J].

Marttila, Saara ;

Tamminen, Hely ;

Rajic, Sonja ;

Mishra, Pashupati P. ;

Lehtimaki, Terho ;

Raitakari, Olli ;

Kahonen, Mika ;

Kananen, Laura ;

Jylhava, Juulia ;

Hagg, Sara ;

Delerue, Thomas ;

Peters, Annette ;

Waldenberger, Melanie ;

Kleber, Marcus E. ;

Marz, Winfried ;

Luoto, Riitta ;

Raitanen, Jani ;

Sillanpaa, Elina ;

Laakkonen, Eija K. ;

Heikkinen, Aino ;

Ollikainen, Miina ;

Raitoharju, Emma .

EPIGENOMICS, 2022, 14 (18) :1105-1124

← 1 2 →