Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: exploratory results from the OPTIMA Study

被引：0

作者：

Bouthillier, Anne ^{[1
,2
]}

Bastien, Gabriel ^{[1
,2
]}

Mcanulty, Christina ^{[1
,2
]}

Bakouni, Hamzah ^{[1
,2
]}

Le Foll, Bernard ^{[3
,4
,5
,6
,7
]}

Socias, M. Eugenia ^{[8
,9
]}

Jutras-Aswad, Didier ^{[1
,2
]}

机构：

[1] Univ Montreal, Fac Med, Dept Psychiat & Addictol, Montreal, PQ, Canada

[2] Ctr Hosp Univ Montreal CRCHUM, Res Ctr, Montreal, PQ, Canada

[3] Ctr Addict & Mental Hlth, Translat Addict Res Lab, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada

[4] Univ Toronto, Fac Med, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[5] Univ Toronto, Fac Med, Dept Family & Community Med, Toronto, ON, Canada

[6] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[7] Waypoint Ctr Mental Hlth Care, Waypoint Res Inst, Penetanguishene, ON, Canada

[8] British Columbia Ctr Subst Use, Vancouver, BC, Canada

[9] Univ British Columbia, Fac Med, Dept Med, Vancouver, BC, Canada

来源：

HARM REDUCTION JOURNAL | 2025年 / 22卷 / 01期

基金：

加拿大健康研究院;

关键词：

Opioid use disorder; Harm reduction; Potential life problems; Opioid agonist treatment; Patient-centered outcomes; Opioid use frequency; QUALITY-OF-LIFE; SUBSTITUTION THERAPY; TREATMENT RETENTION; ALCOHOL TREATMENT; COCAINE USE; DRUG-USE; OUTCOMES; SEVERITY; DEPENDENCE; METHADONE;

D O I：

10.1186/s12954-025-01157-4

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

BackgroundTraditional treatment approaches for prescription-type opioid use disorder (POUD), centered on abstinence, have limitations and hinder the development of interventions that meet the needs of people with POUD. Reduction in use without complete abstinence presents a promising avenue for intervention enhancement, but supporting data is scarce regarding its translation into positive patient outcomes. This study explores whether reducing opioid use frequency (OUF) during opioid agonist treatment correlates with reduced potential life problems in individuals with POUD, including those using fentanyl.MethodsThis study is an exploratory analysis of the OPTIMA trial, a pragmatic, open-label, randomized controlled study comparing the effectiveness of flexible take-home dosing of buprenorphine/naloxone and supervised methadone in reducing opioid use amongst individuals with POUD. OUF was assessed every two weeks for 24 weeks after treatment initiation using the Timeline Followback. Potential life problems were evaluated at baseline and study completion using the Addiction Severity Index Self-Report. The 114 participants who completed both baseline and end-of-study questionnaires were included. A repeated-measures generalized linear mixed model (GLMM) was used to evaluate the influence of OUF on potential life problems.ResultsReducing OUF was significantly associated with fewer problems related to medical status (p = 0.049), psychiatric status (p = 0.019), and alcohol problem severity (p = 0.001). The interaction was non-significant for employment (p = 0.264), family status (p = 0.352) and legal status (p = 0.050). Life improvements emerged with <= 21 days of opioid use per 28-day period.ConclusionFindings underscore the significance of harm reduction goals focusing on opioid use reduction, which translated in improvements across many life domains.Trial registrationStudy was registered with ClinicalTrials.gov (NCT03033732) prior to participant enrollment.

引用

页数：13

共 66 条

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