Urinary presepsin is a novel biomarker capable of directly assessing monocyte/macrophage infiltration in kidney diseases

被引:1
作者
Niwa, Shunsuke [1 ]
Tanaka, Akihito [2 ]
Furuhashi, Kazuhiro [2 ]
Hattori, Keita [1 ]
Onogi, Chikao [1 ]
Sunohara, Keisuke [1 ]
Owaki, Akiko [1 ]
Kato, Akihisa [1 ]
Kawazoe, Tomohiro [1 ]
Watanabe, Yu [1 ]
Koshi-Ito, Eri [1 ]
Kato, Noritoshi [1 ]
Kosugi, Tomoki [1 ]
Maruyama, Shoichi [1 ]
机构
[1] Nagoya Univ, Grad Sch Med, Dept Nephrol, 65 Tsuruma Cho,Showa Ku, Nagoya, Aichi, Japan
[2] Nagoya Univ Hosp, Dept Nephrol, 65 Tsuruma Cho,Showa Ku, Nagoya, Aichi, Japan
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
Biomarkers; Kidney diseases; Presepsin; Urinary level; SOLUBLE CD163; RENAL BIOPSY; DIAGNOSIS; SCD14-ST; SEPSIS;
D O I
10.1038/s41598-024-80686-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Serum presepsin levels are elevated during sepsis and are widely employed in clinical practice. However, the association between urinary presepsin and kidney diseases remains elusive. Given that monocytes/macrophages, primary presepsin producers, are closely associated with the pathophysiology of nephritis, we explored the potential of urinary presepsin as a kidney disease biomarker. In a cross-sectional study involving patients who underwent kidney biopsy (n = 463 patients; 43% female, median age 58 years), the median urinary presepsin/creatinine levels were 590 (interquartile range [IQR], 244-1276), 1023 (IQR, 491-2749), 1429 (IQR, 644-2725), and 3518 (IQR, 2084-6321) ng/g creatinine, indicating minimal (< 5%), mild (5-25%), moderate (26-50%), and severe (> 50%) interstitial inflammatory cell infiltration in biopsy samples, respectively. The area under the curve of urinary presepsin/creatinine (0.81) had a higher accuracy for distinguishing severe interstitial inflammatory cell infiltration than that of the N-acetyl-beta-D-glucosaminidase/creatinine (0.70) (P = 0.003). The tubulointerstitial nephritis group had the highest urinary presepsin/creatinine level. Immunofluorescence staining revealed that monocytes and macrophages predominantly expressed presepsin in the kidney interstitium, with the stained area positively and significantly correlated with presepsin/creatinine values (r = 0.57, P = 0.02). Urinary presepsin could be a biomarker for directly assessing monocyte/macrophage infiltration in kidney disease.
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页数:12
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