Rhodium(III)-Catalyzed Sequential Cyclization of Enaminones with 1,3-Dienes via C-H Activation for the Synthesis of Fluorenones

被引：1

作者：

Gao, Lei ^{[1
,2
]}

Wang, Min ^{[2
]}

Ren, Hongwei ^{[2
]}

Yao, Jinzhong ^{[2
]}

Miao, Maozhong ^{[1
]}

Zhou, Hongwei ^{[2
]}

机构：

[1] Zhejiang Sci Tech Univ, Dept Chem, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Zhejiang, Peoples R China

[2] Jiaxing Univ, Coll Biol & Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 90卷 / 01期

基金：

中国国家自然科学基金;

关键词：

FRIEDEL-CRAFTS ACYLATION; FUNCTIONALIZATION; OXYGENATION; DIVERGENT; CLEAVAGE; ACCESS;

D O I：

10.1021/acs.joc.4c01956

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for construction of various fluorenones has been achieved via Rh(III)-catalyzed C-H activation/[4 + 2] annulation/aromatization sequences of simple and readily available enaminones and 1,3-dienes. This protocol showed good substrate compatibility as an array of structurally and electronically diverse fluorenones prepared efficiently in moderate to good yields and preparative scale utility showing very good efficiency in the late-stage functionalization of complex valuable molecules.

引用

页码：116 / 123

页数：8

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