Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer

被引：1

作者：

Mussa, Ali ^{[1
,2
]}

Ismail, Nor Hayati ^{[1
]}

Hamid, Mahasin ^{[3
,4
]}

Al-Hatamleh, Mohammad A. I. ^{[5
]}

Bragoli, Anthony ^{[6
]}

Hajissa, Khalid ^{[7
]}

Mokhtar, Noor Fatmawati ^{[8
]}

Mohamud, Rohimah ^{[9
]}

Uskokovic, Vuk ^{[10
,11
]}

Hassan, Rosline ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Haematol, 16150 Kubang Kerian, Kelantan, Kota Bharu, Malaysia

[2] Omdurman Islamic Univ, Fac Educ, Dept Math, POB 382, Omdurman, Sudan

[3] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Pharmaceut, Changsha 410013, Hunan Province, Peoples R China

[4] Univ Nyala, Fac Sci & Informat Technol, Dept Math, Nyala 6331, Sudan

[5] Univ Pittsburgh, UPMC Hillman Canc Ctr, Dept Med, Div Hematol & Oncol, Pittsburgh, PA 15213 USA

[6] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15260 USA

[7] Omdurman Islamic Univ, Fac Sci & Technol, Dept Zool, POB 382, Omdurman, Sudan

[8] Univ Sains Malaysia, Inst Res Mol Med INFORMM, Kubang Kerian 16150, Kelantan, Malaysia

[9] Univ Sains Malaysia, Sch Med Sci, Dept Haematol, 16150 Kubang Kerian, Kelantan, Kota Bharu, Malaysia

[10] TardigradeNano LLC, Irvine, CA 92604 USA

[11] Fullerton Coll, Div Nat Sci, Fullerton, CA 92832 USA

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2024年 / 43卷 / 01期

关键词：

Immune checkpoint; Immunosuppressive TME; TNF; TNFRSF1B; CD120b; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; FACTOR RECEPTOR 2; EPITHELIAL-MESENCHYMAL TRANSITION; CHIMERIC ANTIGEN RECEPTORS; SUPPRESSOR-CELLS; STEM-CELLS; BISPECIFIC ANTIBODY; DENDRITIC CELLS;

D O I：

10.1186/s13046-024-03218-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer (BC) is the most frequently diagnosed malignancy among women. It is characterized by a high level of heterogeneity that emerges from the interaction of several cellular and soluble components in the tumor microenvironment (TME), such as cytokines, tumor cells and tumor-associated immune cells. Tumor necrosis factor (TNF) receptor 2 (TNFR2) appears to play a significant role in microenvironmental regulation, tumor progression, immune evasion, drug resistance, and metastasis of many types of cancer, including BC. However, the significance of TNFR2 in BC biology is not fully understood. This review provides an overview of TNFR2 biology, detailing its activation and its interactions with important signaling pathways in the TME (e.g., NF-kappa B, MAPK, and PI3K/Akt pathways). We discuss potential therapeutic strategies targeting TNFR2, with the aim of enhancing the antitumor immune response to BC. This review provides insights into role of TNFR2 as a major immune checkpoint for the future treatment of patients with BC.

引用

页数：53

共 342 条

[31] Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer [J].