Comparative lifespan and healthspan of nonhuman primate species common to biomedical research

被引：0

作者：

Hillary F. Huber ^{[1
]}

Hannah C. Ainsworth ^{[2
]}

Ellen E. Quillen ^{[2
]}

Adam Salmon ^{[3
]}

Corinna Ross ^{[1
]}

Adinda D. Azhar ^{[4
]}

Karen Bales ^{[5
]}

Michele A. Basso ^{[6
]}

Kristine Coleman ^{[7
]}

Ricki Colman ^{[8
]}

Huda S. Darusman ^{[9
]}

William Hopkins ^{[10
]}

Charlotte E. Hotchkiss ^{[4
]}

Matthew J. Jorgensen ^{[11
]}

Kylie Kavanagh ^{[12
]}

Cun Li ^{[13
]}

Julie A. Mattison ^{[7
]}

Peter W. Nathanielsz ^{[2
]}

Suryo Saputro ^{[2
]}

Diana G. Scorpio ^{[15
]}

Paul-Michael Sosa ^{[14
]}

Eric J. Vallender ^{[16
]}

Yaomin Wang ^{[1
]}

Caroline J. Zeiss ^{[14
]}

Carol A. Shively ^{[4
]}

Laura A. Cox ^{[1
]}

机构：

[1] Texas Biomedical Research Institute, San Antonio, TX

[2] Wake Forest University School of Medicine, Winston-Salem, NC

[3] University of Texas Health Science Center, San Antonio, TX

[4] Primate Research Center, IPB University, Bogor

[5] California National Primate Research Center, Davis, CA

[6] University of California, Davis, CA

[7] Washington National Primate Research Center, Seattle, WA

[8] Oregon National Primate Research Center, Hillsboro, OR

[9] Science University, Portland, OR

[10] Wisconsin National Primate Research Center, Madison, WI

[11] School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor

[12] The University of Texas MD Anderson Cancer Center, Bastrop, TX

[13] Emory National Primate Research Center, Atlanta, GA

[14] University of Wyoming, Laramie, WY

[15] University of Tasmania, Hobart, TAS

[16] National Institute On Aging, National Institutes of Health, Gaithersburg, MD

[17] Envol Biomedical, Immokalee, FL

[18] Tulane National Primate Research Center, Covington, LA

[19] New England Primate Research Center, Southborough, MA

[20] Yale University School of Medicine, New Haven, CT

来源：

GeroScience | 2025年 / 47卷 / 1期

基金：

美国国家卫生研究院;

关键词：

Aging; Healthspan; Lifespan; Longevity; Nonhuman primates; Survival; Translational;

D O I：

10.1007/s11357-024-01421-8

中图分类号：

学科分类号：

摘要：

There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan–Meier survival curves were computed in 12 translational aging models: baboon, bonnet macaque, chimpanzee, common marmoset, coppery titi monkey, cotton-top tamarin, cynomolgus macaque, Japanese macaque, pigtail macaque, rhesus macaque, squirrel monkey, and vervet/African green. After employing strict inclusion criteria, primary results are based on 12,269 NHPs that survived to adulthood and died of natural/health-related causes. A secondary analysis was completed for 32,616 NHPs that died of any cause. Results show a pattern of reduced male survival among catarrhines (African and Asian primates), especially macaques, but not platyrrhines (Central and South American primates). For many species, median lifespans were lower than previously reported. An important consideration is that these analyses may offer a better reflection of healthspan than lifespan since research NHPs are typically euthanized for humane welfare reasons before their natural end of life. This resource represents the most comprehensive characterization of sex-specific lifespan and age-at-death distributions for 12 biomedically relevant species, to date. These results clarify relationships among NHP ages and provide a valuable resource for the aging research community, improving human-NHP age equivalencies, informing investigators of expected survival rates, providing a metric for comparisons in future studies, and contributing to understanding of factors driving lifespan differences within and among species. © The Author(s), under exclusive licence to American Aging Association 2024.

引用

页码：135 / 151

页数：16

共 61 条

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