Early onset metastatic colorectal cancer patients as a distinctive clinical and molecular phenomenon

被引：1

作者：

Pretta, Andrea ^{[1
,2
]}

Ziranu, Pina ^{[1
,2
]}

Perissinotto, Eleonora ^{[3
,4
]}

Ghelardi, Filippo ^{[5
]}

Marmorino, Federica ^{[6
,7
]}

Giampieri, Riccardo ^{[8
,9
]}

Puci, Mariangela ^{[10
]}

De Grandis, Maria Caterina ^{[3
,4
]}

Lai, Eleonora ^{[1
,2
]}

Nasca, Vincenzo ^{[5
]}

Ciraci, Paolo ^{[6
,7
]}

Puzzoni, Marco ^{[1
]}

Cerma, Krisida ^{[3
]}

Sciortino, Carolina ^{[5
]}

Taravella, Ada ^{[6
,7
]}

Pretta, Gianluca ^{[11
]}

Giuliani, Lorenzo ^{[8
,9
]}

Damonte, Camilla ^{[5
]}

Pusceddu, Valeria ^{[1
,2
]}

Sotgiu, Giovanni ^{[10
]}

Berardi, Rossana ^{[8
,9
]}

Lonardi, Sara ^{[3
]}

Bergamo, Francesca ^{[3
]}

Pietrantonio, Filippo ^{[5
]}

Cremolini, Chiara ^{[6
,7
]}

Scartozzi, Mario ^{[1
,2
]}

机构：

[1] Univ Hosp, Med Oncol Unit, Cagliari, Italy

[2] Univ Cagliari, Cagliari, Italy

[3] IRCCS, Veneto Inst Oncol IOV, Dept Oncol, Padua, Italy

[4] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy

[5] Fdn IRCCS Ist Nazl Tumori, Med Oncol Dept, Milan, Italy

[6] Univ Hosp Pisa, Unit Oncol, Pisa, Italy

[7] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy

[8] Molecolari Univ Politecn Marche, Clin Oncolog Dipartimento Sci Clin, Ancona, Italy

[9] Azienda Ospedaliero Univ Marche Ancona, Ancona, Italy

[10] Univ Sassari, Dept Med Surg & Expt Sci, Clin Epidemiol & Med Stat Unit, Sassari, Sardinia, Italy

[11] Kings Sch Hove, Sci Dept, Hangleton, England

来源：

BRITISH JOURNAL OF CANCER | 2025年 / 132卷 / 02期

关键词：

YOUNG-ADULTS; INCREASING INCIDENCE; COLON-CANCER; AGE; SURVIVAL; PATTERNS; ASSOCIATION; STATISTICS; DIAGNOSIS; FEATURES;

D O I：

10.1038/s41416-024-02902-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Despite a reduction of both incidence and mortality from CRC, recent studies have shown an increase in the incidence of early-onset CRC (EO-CRC). Data on this setting are limited. The aim of our study was to evaluate the clinical and molecular profiles of metastatic EO-CRC patients in order to identify differences compared to a late-onset CRC (LO-CRC) control group. Methods: We retrospectively collected data from 1272 metastatic colorectal cancers from 5 different Italian Institutions. The main objective was to the evaluate clinical outcome for EO-CRC patients in comparison to patients included in the control group. Results: In the overall population, mOS was 34,7 in EO-CRC pts vs 43,0 months (mo) (p < 0,0001). In the RAS/BRAF mutated subgroup mOS in EO-CRC pts was 30,3 vs 34,0 mo (p = 0,0156). In RAS/BRAF wild-type EO-CRC mOS was 43,0 vs 50,0 mo (p = 0,0290). mPFS was 11,0 in EO-CRC pts vs 14,0 mo (p < 0,0001). Conclusion: Findings indicate a general worse prognosis for patients with early-onset colorectal cancer compared to late-onset patients. Interestingly this seems to occur regardless of the molecular status. These observations might have a considerable impact on clinical practice and research.

引用

页码：188 / 194

页数：7

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