Clinical outcomes and safety of CAR-T cells in treatment of T-Cell acute lymphoblastic leukemia/lymphoma

被引：0

作者：

Ma, Jin-Feng ^{[1
,2
]}

Yan, Chun-Long ^{[3
]}

Jia, Xu ^{[4
]}

Zhu, Hong-Jia ^{[4
]}

Yan, Jia-Wei ^{[2
,5
]}

Liu, Mei-Jing ^{[2
,5
]}

Zhang, Dai-Yi ^{[6
]}

Liu, Shen-Hao ^{[2
,5
]}

Xu, Nan ^{[4
]}

Zhang, Hai-Guo ^{[1
]}

Ye, Ling ^{[1
]}

Yu, Lei ^{[4
]}

Wu, De-Pei ^{[2
,5
]}

Gong, Wen-Jie ^{[2
,5
]}

Dai, Hai-Ping ^{[2
,5
]}

Xue, Sheng-Li ^{[2
,5
]}

机构：

[1] Jining 1 Peoples Hosp, Jining, Peoples R China

[2] Soochow Univ, Jiangsu Inst Hematol, Affiliated Hosp 1, Natl Clin Res Ctr Hematol Dis, Suzhou, Peoples R China

[3] Capital Med Univ, Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Radiol, Beijing, Peoples R China

[4] Shanghai Unicar Therapy Biomed Technol Co Ltd, Res & Dev Dept, Shanghai, Peoples R China

[5] Soochow Univ, Inst Blood & Marrow Transplantat, Collaborat Innovat Ctr Hematol, Suzhou, Peoples R China

[6] Soochow Univ, Affiliated Hosp 1, Hlth Management Ctr, Suzhou 215006, Jiangsu, Peoples R China

来源：

ANNALS OF HEMATOLOGY | 2025年 / 104卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

T-cell acute lymphoblastic leukemia/lymphoma; Chimeric antigen receptor T-cell; Extramedullary disease; CHIMERIC ANTIGEN RECEPTOR; LEUKEMIA; THERAPY; CD7; LYMPHOMA; EXPRESSION; CHILDREN; DISEASE; ADULTS;

D O I：

10.1007/s00277-024-06132-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Relapsed or refractory T-cell acute lymphoblastic leukemia/lymphoma (r/r T-ALL/LBL) are frequently aggressive and associated with unfavorable prognoses. Pan-targeted Chimeric Antigen Receptor (CAR) T-cell therapy have shown promising results in clinical trials. In recent years, CD7 CAR T-cell and CD5 CAR T-cell demonstrate effectiveness in treating r/r T-ALL/LBL patients with bone marrow infiltration. However, nearly half of r/r T-ALL/T-LBL patients are accompanied by extramedullary disease (EMD), where comprehensive data on the efficacy and safety of CAR T-cell therapy remain limited. Additionally, CD7 CAR T-cell and CD5 CAR T-cell therapy can cause severe immunodeficiency and hematologic toxicity, complicating with difficult immune reconstitution. This review provides an in-depth analysis of the safety profile and adverse events associated with CAR T-cell therapy in r/r T-ALL/LBL, with a a particular emphasis on its impact in patients with EMD.

引用

页码：57 / 63

页数：7

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