Short-chain fatty acids play a key role in antibody response to SARS-CoV-2 infection in people living with HIV

被引：0

作者：

Pan, Jingying ^{[1
,3
]}

Zhang, Xiaodi ^{[1
]}

Shi, Danrong ^{[1
]}

Tian, Xuebin ^{[1
]}

Xu, Lijun ^{[1
]}

Lu, Xiangyun ^{[1
]}

Dong, Mingqing ^{[2
]}

Yao, Peng ^{[2
]}

Pan, Zhaoyi ^{[3
]}

Ling, Zongxin ^{[1
]}

Wu, Nanping ^{[3
]}

Yao, Hangping ^{[1
,3
]}

机构：

[1] Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Natl Clin Res Ctr Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Hangzhou 310000, Peoples R China

[2] Zhejiang Univ, Zhejiang Qingchun Hosp, Dept Infect Dis, Hangzhou 310000, Peoples R China

[3] Jinan Microecol Biomed Shandong Lab, Jinan 250000, Peoples R China

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

Gut microbiome; SARS-CoV-2; Immune response; People living with HIV; Short-chain fatty acid; GUT MICROBIOME; IMMUNITY;

D O I：

10.1038/s41598-024-82596-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

High SARS-CoV-2-specific antibody levels can protect against SARS-CoV-2 reinfection. The gut microbiome can affect a host's immune response. However, its role in the antibody response to SARS-CoV-2 in people living with HIV (PLWH) remains poorly understood. Here, we categorised PLWH and healthy individuals into high- and low-antibody-response groups. Shotgun metagenomic sequencing and targeted metabolomic assays were used to investigate the differences in the gut microbiome and metabolic functions between the high- and low-antibody-response groups. PLWH demonstrated a higher abundance of short-chain fatty acid (SCFA)-producing species, accompanied by high serum levels of several SCFAs, in the high-antibody-response group than in the low-antibody-response group. In contrast, healthy individuals demonstrated higher enrichment of pilus-bearing bacterial species, with flagella-expressing genes, in the high-antibody-response group than in the low-antibody-response group. Therefore, gut-microbiota-derived SCFAs play a key role in antibody responses in PLWH but not in healthy individuals. Our results afford a novel understanding of how the gut microbiome and its metabolites are associated with host immunity. Moreover, they may facilitate the exploration of modalities to prevent SARS-CoV-2 reinfection through various gut-microbiota-targeted interventions tailored to different populations.

引用

页数：14

共 44 条

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