Radiation-induced heart disease in breast cancer patients: a narrative review of epidemiology, risk factors, radiotherapy parameters, and prevention

被引：2

作者：

van der Vorst, Aline ^{[1
,2
]}

Lambrecht, Maarten ^{[1
,2
]}

Van Aelst, Lucas ^{[3
,4
]}

Verhoeven, Jelle ^{[2
]}

Jacobs, Johanna ^{[3
,4
]}

Baten, Adinda ^{[2
]}

Weltens, Caroline ^{[1
,2
]}

机构：

[1] UZ Leuven, Lab Expt Radiotherapy, Leuven, Belgium

[2] UZ Leuven, Dept Radiat Oncol, Leuven, Belgium

[3] UZ Leuven, Lab Clin Cardiol, Leuven, Belgium

[4] UZ Leuven, Dept Cardiol, Leuven, Belgium

来源：

STRAHLENTHERAPIE UND ONKOLOGIE | 2025年 / 201卷 / 04期

关键词：

Breast cancer; Radiotherapy; Cardiac toxicity; Heart-sparing techniques; DESCENDING CORONARY-ARTERY; POSITIVE AIRWAY PRESSURE; PROTON THERAPY; HOLD TECHNIQUE; WOMEN; MORTALITY; PRONE; METAANALYSIS; TRIALS; COHORT;

D O I：

10.1007/s00066-024-02362-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundBreast cancer is the most prevalent cancer in women worldwide; nevertheless, the prognosis is good, with a 5-year overall survival of 80-90%. Therefore, it becomes crucial to strive for high quality of life after cure by minimizing treatment-related toxicity. One such concern is radiation-induced heart disease, which remains a significant focus of ongoing investigations.PurposeThe aim of this review is to summarize current knowledge on radiation-induced heart disease in breast cancer patients by giving an overview of its epidemiology, risk factors, radiation parameters related to its development, solutions in radiation practice, and prevention. The goal is to raise awareness and maximize prevention of radiation-induced heart disease.MethodsThe PubMed database was screened for articles published between January 2013 and November 2023 related to the keywords , <radiotherapy>, <cardiac toxicity>, and <heart-sparing techniques>. Moreover, by screening the literature lists of these publications, additional articles were added.ResultsNinety-four relevant papers remained for final review.ConclusionRadiation-induced heart disease is a rare complication after breast cancer radiotherapy and represents a clinical spectrum of various cardiovascular conditions. Several heart-sparing techniques have been developed, and more attention has been paid to early diagnosis and prevention of radiation-induced heart disease. However, further research remains important to refine radiotherapy techniques and deepen our understanding for improved prevention and treatment of this condition in the future. This clinical review summarizes the existing evidence and literature on radiation-induced heart disease following modern breast cancer radiotherapy, offering clinical guidance for physicians.

引用

页码：368 / 382

页数：15

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