Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity

被引：0

作者：

Xu, Ziyang ^{[1
,2
]}

Su, Bing ^{[1
,2
,3
,4
,5
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Dept Immunol & Microbiol, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Ctr Immune Related Dis, Dept Gastroenterol,Sch Med, Shanghai, Peoples R China

[3] Cent South Univ, Xiangya Hosp, Dept Oncol, Xiangya Canc Ctr, Changsha, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

[5] Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ Sch Med Yale Inst Immune M, Sch Med, Shanghai, Peoples R China

来源：

NATURE IMMUNOLOGY | 2025年 / 26卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

FOXP3;

D O I：

10.1038/s41590-024-02071-w

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a novel human tonsil immune organoid system, Chen et al. demonstrate that by controlling autoreactive humoral and cellular responses, human CD4+ regulatory T cells (Treg cells) and CD8+ Treg cells cooperatively restrain the otherwise uncontrolled autoimmune disease progression.

引用

页码：159 / 160

页数：2

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