Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity

被引：0
|
作者：
Xu, Ziyang [1 ,2 ]
Su, Bing [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Dept Immunol & Microbiol, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Ctr Immune Related Dis, Dept Gastroenterol,Sch Med, Shanghai, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Dept Oncol, Xiangya Canc Ctr, Changsha, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
[5] Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ Sch Med Yale Inst Immune M, Sch Med, Shanghai, Peoples R China
来源：
NATURE IMMUNOLOGY | 2025年 / 26卷 / 02期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
FOXP3;
D O I：
10.1038/s41590-024-02071-w
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Using a novel human tonsil immune organoid system, Chen et al. demonstrate that by controlling autoreactive humoral and cellular responses, human CD4+ regulatory T cells (Treg cells) and CD8+ Treg cells cooperatively restrain the otherwise uncontrolled autoimmune disease progression.
引用
收藏
页码：159 / 160
页数：2
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