Formulation, characterisation and comparison of different raloxifene hydrochloride loaded lipid-polymer hybrid nanoparticles

被引：1
作者：
Mahmood S. [1 ]
Phey T.C. [1 ]
Kheng L.S. [1 ]
Chen K.P. [1 ]
Mandal U.K. [2 ]
机构：
[1] Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, University Malaysia Pahang, Gambang
[2] Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda
来源：
International Journal of Nano and Biomaterials | 2020年 / 9卷 / 3-4期
关键词：
Lipid-polymeric hybrid nanoparticle; LPHNP; Pharmacokinetic release modelling; Raloxifene; Release study;
D O I：
10.1504/IJNBM.2020.112224
中图分类号：
学科分类号：
摘要：
This study aims to formulate raloxifene loaded lipid-polymeric hybrid nanoparticles (LPHNPs) and the comparison of their properties. Three LPHNPs, each with phosphatidylcholine-lipid (PCL) as bilayer-formingmembrane with three different polymers like sodium alginate, chitosan and poly(lactic-co-glycolic-acid) were prepared by nanoprecipitation, solvent injection and emulsion solvent evaporation, respectively. Results showed that the prepared formulations were spherical-shaped with a heterogeneity. Surface morphology was viewed using a scanning electron microscopy (SEM). A high entrapment efficiency (>70%) with a sustained and pH dependent drug release profile for 24 h was observed and evaluated using mathematical kinetic modelling. Fourier transform infrared spectroscopy was used to confirm successful entrapment of raloxifene after evaluating the interaction and compatibility of the excipients used. Whereas, differential scanning calorimetry and X-ray diffraction revealed the transformation of raloxifene into an amorphous form. In conclusion, these hybrid nanoparticles provide a promising approach for oral delivery of raloxifene. © 2020 Inderscience Enterprises Ltd.
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页码：123 / 141
页数：18
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