Association between geriatric nutritional risk index and clinical outcome of elderly aneurysmal subarachnoid hemorrhage patients: insights from a large cohort study

Geriatric nutritional risk index (GNRI), a simple, objective index for evaluating nutritional status of elderly patients, is demonstrated to be associated with the prognosis of several diseases. This study aims to explore the association between GNRI and prognosis of elderly aneurysmal subarachnoid hemorrhage (aSAH) patients. A total of 168 patients older than 65 years old were included in this research. The modified Rankin Scale (mRS) was applied to assess the prognosis of patients. Favorable outcome was defined as mRS <3 and unfavorable outcome was defined as mRS >= 3. The GNRI, calculated by albumin, height, and weight, was used to evaluate the nutritional status of elderly patients. Multivariate logistic regression was performed to identify the association between GNRI and prognosis of elderly aSAH patients. Compared with unfavorable outcome groups, favorable outcome group had higher GNRI level. After adjusting for several important factors, multivariate logistics regression analysis showed that low GNRI was associated with higher risk of unfavorable outcome. The receiver operating curve (ROC) analysis demonstrated that the area under the curve (AUC) was 0.720, which meant GNRI might be a reliable prognostic predictor. A low GNRI was independently associated with unfavorable outcome of elderly aSAH patients. The registration number is NCT04785976 and the registration data is February 2021.