Scutellaria baicalensis Extract Inhibits the UVA-induced Photoaging in NIH3T3 Cells

被引：0

作者：

Cai C. ^{[1
]}

Huang Y. ^{[1
]}

Li L. ^{[1
]}

Yu Y. ^{[2
]}

Liu X. ^{[2
]}

Xiao S. ^{[2
]}

Lu L. ^{[1
]}

机构：

[1] School of Life Science and Biopharmaceutical, Guangdong Pharmaceutical University, Guangzhou

[2] Guangdong Institute for Drug Control, NMPA Key Laboratory for Safety Risk Assessment of Cosmetics, Guangzhou

来源：

Science and Technology of Food Industry | 2024年 / 45卷 / 12期

关键词：

anti-aging; photoaging; plant extract; Scutellaria baicalensis;

D O I：

10.13386/j.issn1002-0306.2023070036

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: To investigate the protective effect of Scutellaria baicalensis extract on ultraviolet (UVA)-induced photoaging in a fibroblast cell line (NIH3T3). Methods: The cellular photoaging model was established by UVA irradiation, and the protective effects of Scutellaria baicalensis extract on photoaging fibroblasts were investigated using CCK-8 assay, β-galactosidase staining, DAPI staining, and immunofluorescence staining. Results: Scutellaria baicalensis extract significantly promoted cell proliferation and migration of NIH3T3 cells (P<0.05), increased the cell viability of NIH3T3 cells after UVA irradiation, reduced UVA-induced cell apoptosis, and the expression of senescence-associated marker βgalactosidase (SA-β-gal). It also promoted the regeneration of endogenous type I and type IV collagen, reversing collagen loss induced by UVA irradiation, collectively contributing to the defense against cellular photoaging. Conclusion: Scutellaria baicalensis extract effectively inhibits the photoaging of NIH3T3 cells induced by UVA irradiation. © The Author(s) 2024.

引用

页码：327 / 333

页数：6

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