A national survey of suicidality and non-suicidal self-injury in bipolar disorder: insights from network analysis

被引：0

作者：

Cui, Lvchun ^{[1
]}

Zhu, Yuncheng ^{[2
,3
]}

Li, Yang ^{[4
]}

Zhou, Jia ^{[4
]}

Xu, Guiyun ^{[5
]}

Pan, Miao ^{[6
]}

Chen, Zhiyu ^{[7
]}

Li, Wenfei ^{[8
]}

Jiao, Zhian ^{[9
]}

Li, Mingli ^{[10
]}

Zhang, Yong ^{[11
]}

Chen, Jingxu ^{[12
]}

Chen, Xiuzhe ^{[13
]}

Li, Na ^{[14
]}

Sun, Jing ^{[15
]}

Zhang, Jian ^{[16
]}

Hu, Shaohua ^{[17
]}

Wu, Haishan ^{[18
]}

Gan, Zhaoyu ^{[19
]}

Qin, Yan ^{[20
]}

Wang, Yumei ^{[21
]}

Ma, Yantao ^{[22
]}

Wang, Xiaoping ^{[18
]}

Li, Xiaohong ^{[4
]}

Wu, Chuangxin ^{[3
]}

Cai, Yiyun ^{[1
]}

Chen, Jiaye ^{[1
]}

Wu, Baichuan ^{[1
]}

Wang, Zuowei ^{[2
,3
]}

Peng, Daihui ^{[1
]}

Fang, Yiru ^{[1
,23
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, 600 Wanping South Rd, Shanghai 200030, Peoples R China

[2] Shanghai Univ, Clin Res Ctr Mental Hlth, Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China

[3] Shanghai Hongkou Mental Hlth Ctr, 159 Tongxin Rd, Shanghai 200083, Peoples R China

[4] Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China

[5] Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China

[6] Xinxiang Med Univ, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China

[7] Hangzhou Seventh Peoples Hosp, Hangzhou 310013, Zhejiang, Peoples R China

[8] Anhui Mental Hlth Ctr, Hefei, Anhui, Peoples R China

[9] Shandong Prov Hosp, Jinan, Shandong, Peoples R China

[10] Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China

[11] Tianjin Anding Hosp, Tianjin, Peoples R China

[12] Beijing Huilongguan Hosp, Beijing, Peoples R China

[13] Shandong Mental Hlth Ctr, Jinan, Shandong, Peoples R China

[14] Kunming Med Univ, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China

[15] Nanjing Brain Hosp, Nanjing, Jiangsu, Peoples R China

[16] Shenzhen Kangning Hosp, Shenzhen, Guangdong, Peoples R China

[17] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou, Zhejiang, Peoples R China

[18] Cent South Univ, Second Xiangya Hosp, Changsha, Hunan, Peoples R China

[19] Zhongshan Univ, 3 Hosp, Guangzhou, Guangdong, Peoples R China

[20] Dalian Seventh Peoples Hosp, Dalian, Liaoning, Peoples R China

[21] Hebei Med Univ, Hosp 1, Shijiazhuang, Hebei, Peoples R China

[22] Peking Univ, Inst Mental Hlth, Beijing, Peoples R China

[23] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China

来源：

BMC PSYCHIATRY | 2025年 / 25卷 / 01期

关键词：

Bipolar disorder; Suicide; Non-suicidal self-injury; Addictive features; Network analysis; INTERNATIONAL SOCIETY; TASK-FORCE; BEHAVIOR; REGRESSION; ADDICTION; DEATHS; RISK; HARM;

D O I：

10.1186/s12888-025-06750-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background There is a high prevalence of suicidal ideation (SI), suicide attempts (SA), and non-suicidal self-injury (NSSI) in bipolar disorder (BD). Understanding the nature of suicidality and NSSI in BD is an important way to inform optimal intervention for reducing suicide risk. We aimed to investigate the prevalence and correlates of SI, SA, and NSSI in patients with BD using data from a national survey. We used network analysis to explore the associations among suicidality, NSSI, addictive features of NSSI, and symptoms of BD. Methods Participants with BD were recruited from 20 research centers in China. Suicidality, NSSI, addictive features, and symptoms of BD were measured via a standardized electronic case report form. We used logistic regression and network analysis for data analysis. Results Of the 1,055 participants recruited, over 50% with depressive or mixed episodes had SI, more than 20% engaged in SA, and over 40% reported NSSI. The polarity of mood episodes was independently associated with SI ([hypo]mania vs. mixed episodes: odds ratio [OR] = 0.22, 95% confidence interval [CI] 0.14-0.33, p < 0.001) and NSSI ([hypo]mania vs. mixed episodes: OR = 0.33, 95% CI 0.19-0.58, p < 0.001; depressive episodes vs. mixed episodes: OR = 0.59, 95% CI 0.35-0.98, p = 0.040). Participants with mixed episodes reported the most severe addictive features of NSSI. SI was the most influential symptom within the network model of the total sample; NSSI, SI, and depressive symptoms were identified as key "bridge symptoms". Conclusions Suicidality and NSSI in BD were closely associated with depressive and mixed episodes, with mixed episodes showing the highest prevalence of NSSI and the most pronounced addictive features. SI was identified as the central symptom within the self-harm network, emphasizing its importance as an intervention target. These findings could offer potential insights regarding suicidality and NSSI in BD that can inform intervention strategies.

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页数：14

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