This study explores the management methods and approaches for patients with vascular Ehlers-Danlos Syndrome (vEDS) in a minimally invasive manner. In this paper, we presented two cases diagnosed with vEDS that presented with multiple aneurysms during their lives which were managed intravascularly, and outcomes were expressed. Two young male cases diagnosed with vEDS complained of numerous femoral, axillar, vertebral, and superior mesenteric artery aneurysms which were managed endovascularly with stent-grafts, coils, and plugs. We aimed to state that managing vascular complications in vEDS patients may be done minimally invasive with no major traditional surgery and should contain a multidisciplinary approach.