Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis

被引：0
作者：
Luan, Biqing [1 ]
Yang, Yang [2 ]
Yang, Qizhi [1 ]
Li, Zhiqiang [1 ]
Xu, Zhihui [1 ]
Chen, Yaqin [1 ]
Wang, Meiting [1 ]
Chen, Wenlin [2 ]
Ge, Fei [1 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 1, Dept Breast Surg, Kunming 650032, Yunnan, Peoples R China
[2] Peking Univ, Kunming Med Univ,Canc Hosp Yunnan, Yunnan Canc Hosp,Affiliated Hosp 3, Yunnan Key Lab Breast Canc Precis Med,Dept breast, Kunming, Yunnan, Peoples R China
来源：
AMB EXPRESS | 2025年 / 15卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Gut microbiota; Pan-cancer; Blood metabolites; Mendelian randomization; Mediation analysis; Metabolic pathway enrichment analysis; SUSCEPTIBILITY LOCI; LUNG-CANCER; ASSOCIATION; INSTRUMENTS; BIAS;
D O I：
10.1186/s13568-025-01866-w
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers. Results were validated through bidirectional two-sample Mendelian Randomization (MR), heterogeneity tests, and pathway enrichment, leading to a mediation pathway model. We identified 129 gut microbiota, 57 pathways, and 463 metabolites linked to cancer, and 34 significant plasma pathways. 15 microbiota, 8 pathways, and 58 metabolites implicated in multiple cancers. Eight plasma metabolic pathways are involved in the development of multiple types of cancer. Through Multivariate Mendelian Randomization (MVMR) and mediation analysis, we found 9 mediation pathways, offering novel targets and research directions for cancer pathogenesis and treatment.
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页数：17
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