The inhibitory effect of salidroside on RANKL-induced osteoclast formation via NFκB suppression

被引：0

作者：

Mendjargal, Adilsaikhan ^{[1
,2
]}

Narmandakh, Shijir ^{[2
,3
,4
]}

Zinamyadar, Munkhjargal ^{[2
,5
]}

Amartuvshin, Egshiglen ^{[2
,6
]}

Bold, Juramt ^{[2
,3
]}

Garmaa, Nandin ^{[2
,3
]}

Sundui, Enebish ^{[2
,5
]}

Dorjkhuu, Amgalanbaatar ^{[2
,3
]}

Amgalanbaatar, Avirmed ^{[2
,3
]}

Odkhuu, Erdenezaya ^{[2
,3
,7
]}

机构：

[1] Mongolian Natl Univ Med Sci, Mongolia Japan Hosp, Bot Garden, Ulaanbaatar 13270, Mongolia

[2] Mongolian Soc Human Anat, Ulaanbaatar, Mongolia

[3] Mongolian Natl Univ Med Sci, Sch Biomed, Dept Anat, Post 48-111,S Zorig St, Ulaanbaatar 14210, Mongolia

[4] Mongolian Natl Univ Med Sci, Grad Sch, Ulaanbaatar, Mongolia

[5] Ach Med Univ, Ach Int Hosp, Dept Morphol, Ulaanbaatar, Mongolia

[6] Mongolian Natl Univ Med Sci, Sch Biomed, Ulaanbaatar, Mongolia

[7] Mongolian Natl Univ Med Sci, Inst Biomed Sci, S Zorig St,Post 48-111, Ulaanbaatar 14210, Mongolia

来源：

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL | 2025年 / 61卷 / 01期

关键词：

Salidroside; Rhodiola rosea; Osteoclast; NFATc1; NUCLEAR-FACTOR; RECEPTOR ACTIVATOR; DOWN-REGULATION; MACROPHAGES; MEDICINE; LIGAND; CELLS;

D O I：

10.1007/s11626-024-00981-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone fractures are a prevalent clinical issue, and recent studies highlighted the promising potential of natural bone healing agents in enhancing fracture repair and regeneration. The regulatory interaction mechanism between osteoblasts and osteoclasts is crucial for bone cell biology and bone disease. In Mongolian medicine, people have used the Rhodiola rosea (R. rosea) extract to accelerate bone healing in bone fractures. Salidroside is a bioactive compound of R. rosea. Salidroside is known to regulate bone metabolism and inhibit the activation of osteoclast cells, but how it affects the differentiation of osteoclasts is unknown. We examined the effect of R. rosea extract and its bioactive compound salidroside on the RANKL-induced osteoclast formation in RAW 264.7 cells. The present study observed that salidroside directly inhibits RANKL-induced TRAP-positive osteoclast formation. Immunoblotting analysis revealed that salidroside inhibited the expression of c-Fos and NFATc1, osteoclastogenic key transcription factors, by suppressing late activation of p65 NF kappa B. Further, the ethanol extracts of R. rosea significantly reduced the RANKL-induced osteoclasts in a dose-dependent manner. In conclusion, salidroside inhibits RANKL-induced osteoclast formation via suppressing the NF kappa B/c-Fos/NFATc1 signalling pathway. R. rosea, a primary source of salidroside, is helpful for bone healing via its inhibitory effect on osteoclast formation.

引用

页码：59 / 66

页数：8