Single-cell immune profiling and validation of PBMCs in the onset of and recovery from herpes zoster

被引：0

作者：

Zheng, Shang ^{[1
]}

Zhang, Shuyao ^{[1
]}

Li, Xiangyao ^{[2
]}

Fei, Yong ^{[1
]}

Yang, Lei ^{[1
]}

Liu, Beibei ^{[1
]}

Shen, Kangli ^{[1
]}

Feng, Qinli ^{[1
]}

Zhou, Qinghe ^{[1
]}

Yao, Ming ^{[1
]}

Xu, Longsheng ^{[1
]}

机构：

[1] Jiaxing Univ, Affiliated Hosp, Dept Anesthesia & Pain Med, Jiaxing 314000, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 4, Sch Med, Yiwu 322000, Peoples R China

来源：

COMMUNICATIONS BIOLOGY | 2024年 / 7卷 / 01期

关键词：

T-CELL; VARICELLA; VIRUS; RESPONSES; CHILDREN; CANCER;

D O I：

10.1038/s42003-024-07289-w

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To gain deeper insights into pathogenesis of herpes zoster, the peripheral blood mononuclear cells (PBMCs) from male patients mostly were subjected to single-cell RNA-seq (scRNA-seq) and ATAC-seq analysis. Here we show a detailed immune cell profile in the onset of and recovery from herpes zoster, revealing proportion alterations of the subpopulations, which were validated by flow cytometric analysis and comparison of blood routine data. The integrative analysis of the transcriptomes and epigenomes provided a comprehensive description and validation of the key changes in peripheral blood. This study may provide deep insight into the immune profile during herpes zoster progression and holds potential clinical significance.

引用

页数：15

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