Maternal polycystic ovary syndrome and Offspring's Risk of Cardiovascular diseases in Childhood and Young Adulthood

被引：0

作者：

Yang, Fen ^{[1
,2
]}

Wang, Ziliang ^{[3
,4
,5
]}

Sorensen, Henrik Toft ^{[6
,7
]}

Janszky, Imre ^{[1
,8
]}

Gissler, Mika ^{[9
,10
,11
]}

Yuan, Wei ^{[3
]}

Miao, Maohua ^{[3
]}

Roos, Nathalie ^{[12
,13
]}

Wikstrom, Anna-Karin ^{[14
]}

Li, Jiong ^{[4
,5
]}

Laszlo, Krisztina D. ^{[1
,15
]}

机构：

[1] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden

[2] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[3] Shanghai Inst Biomed & Pharmaceut Technol, Shanghai MOST Key Lab Hlth & Dis Genom, NHC Key Lab Reprod Regulat, Shanghai, Peoples R China

[4] Aarhus Univ Hosp, Dept Clin Med, Aarhus, Denmark

[5] Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark

[6] Aarhus Univ, Ctr Populat Med, Dept Clin Epidemiol, Aarhus, Denmark

[7] Aarhus Univ Hosp, Aarhus, Denmark

[8] Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, Trondheim, Norway

[9] Finnish Inst Hlth & Welf, Dept Hlth Secur, Helsinki, Finland

[10] Reg Stockholm, Acad Primary Hlth Care Ctr, Stockholm, Sweden

[11] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden

[12] Karolinska Inst, Div Clin Epidemiol, Dept Med Solna, Stockholm, Sweden

[13] Karolinska Inst, Stockholm, Sweden

[14] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden

[15] Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

瑞典研究理事会;

关键词：

HEART-DISEASE; BIRTH-WEIGHT; PREGNANCY; HEALTH; WOMEN;

D O I：

10.1038/s41467-024-54795-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Children born to mothers with polycystic ovary syndrome have a higher prevalence of cardiovascular risk factors and of subclinical cardiovascular disease, but the association between maternal polycystic ovary syndrome and cardiovascular disease in offspring is unclear. We conduct a register-based cohort study of 6 839 703 live singleton births from Denmark (1973-2016) and Sweden (1973-2014) and follow them for up to 48 years. Using Cox regression models, we find that offspring of mothers with polycystic ovary syndrome have a higher risk of overall cardiovascular diseases and of its specific subtypes, independently of comorbidities related to polycystic ovary syndrome. Cousin analyzes suggest that familial confounding does not explain our results. If our findings are replicated by future studies, children of women with polycystic ovary syndrome may benefit from early cardiovascular prevention efforts. Maternal polycystic ovary syndrome may impact the offspring's long-term health. Here, the authors show that children of mothers with polycystic ovary syndrome have an increased risk of cardiovascular disease in childhood and young adulthood.

引用

页数：10

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