Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

被引：0

作者：

Suzuki, Yuya ^{[1
]}

Emoto, Takuo ^{[1
]}

Sato, Shunsuke ^{[2
]}

Yoshida, Takeshi ^{[3
]}

Shoda, Mitsuhiko ^{[1
]}

Endoh, Hiromi ^{[4
]}

Nagao, Manabu ^{[5
]}

Hamana, Tomoyo ^{[1
]}

Inoue, Taishi ^{[6
]}

Hayashi, Tomohiro ^{[1
]}

Nitta, Eriko ^{[4
]}

Konishi, Hiroki ^{[7
]}

Kiuchi, Kunihiko ^{[1
]}

Takami, Mitsuru ^{[1
]}

Imamura, Kimitake ^{[1
,8
]}

Taniguchi, Masayuki ^{[9
]}

Inoue, Masatoshi ^{[3
]}

Nakamura, Toshihiro ^{[1
]}

Sonoda, Yusuke ^{[1
]}

Takahara, Hiroyuki ^{[1
]}

Nakasone, Kazutaka ^{[1
]}

Yamamoto, Kyoko ^{[1
]}

Tani, Kenichi ^{[1
]}

Iwai, Hidehiro ^{[1
]}

Nakanishi, Yusuke ^{[1
]}

Yonehara, Shogo ^{[1
]}

Murakami, Atsushi ^{[1
]}

Toh, Ryuji ^{[5
]}

Ohkawa, Takenao ^{[3
]}

Furuyashiki, Tomoyuki ^{[9
]}

Nitta, Ryo ^{[4
]}

Yamashita, Tomoya ^{[1
,10
]}

Hirata, Ken-ichi ^{[1
]}

Fukuzawa, Koji ^{[1
,8
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc Med, Kobe, Japan

[2] Yodogawa Christians Hosp, Dept Surg, Div Cardiovasc Surg, OSAKA, Japan

[3] Kobe Univ, Dept Informat & Intelligence Engn, Kobe, Japan

[4] Kobe Univ, Dept Physiol & Cell Biol, Div Struct Med & Anat, Grad Sch Med, Kobe, Japan

[5] Kobe Univ, Div Evidence Based Lab Med, Grad Sch Med, Kobe, Japan

[6] Kobe Univ, Dept Surg, Div Cardiovasc Surg, Grad Sch Med, Kobe, Japan

[7] Yodogawa Christians Hosp, Dept Internal Med, Div Cardiovasc Med, OSAKA, Japan

[8] Kobe Univ, Dept Internal Med, Div Cardiovasc Med, Sect Arrhythmia,Grad Sch Med, Kobe, Japan

[9] Kobe Univ, Grad Sch Med, Div Pharmacol, Kobe, Japan

[10] Kobe Univ, Grad Sch Sci, Div Adv Med Sci Technol & Innovat, Kobe, Japan

来源：

COMMUNICATIONS BIOLOGY | 2024年 / 7卷 / 01期

基金：

日本学术振兴会;

关键词：

RESIDENT CARDIAC MACROPHAGES; GROWTH; FIBRONECTIN; INFLAMMATION; RECRUITMENT; ACTIVATION; LANDSCAPE; NO;

D O I：

10.1038/s42003-024-07308-w

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Atrial fibrillation (AF) is strongly associated with strokes, heart failure, and increased mortality. This study aims to identify the monocyte-macrophage heterogeneity and interactions of these cells with non-immune cells, and to identify functional biomarkers in patients with AF. Therefore, we assess the single cell landscape of left atria (LA), using a combination of single cell and nucleus RNA-seq. Myeloid cells in LA tissue are categorized into five macrophage clusters, three monocyte clusters, and others. Cell-Chat analysis revealed that monocytes and IL1B+ macrophages send epidermal growth factor (EGF) signals to fibroblasts. Amphiregulin (AREG) is the most upregulated gene in monocytes and IL1B+ macrophages in the AF group, compared with healthy controls from other groups. Serum AREG levels are higher in patients with persistent AF. These data suggested that EGF signaling pathway could be a therapeutic target for AF and serum AREG levels provide an effective biomarker for predicting persistent AF.

引用

页数：13

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