Association between serum uric acid levels and arterial stiffness in patients with psoriasis

This study examined the association between serum uric acid levels (SUA) and arterial stiffness in patients with psoriasis vulgaris. A cross-sectional study was conducted on 205 consecutive patients with psoriasis vulgaris who visited the Dermatology Clinic of China-Japan Friendship Hospital between March 2022 and July 2024. Arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). The patients were divided into four groups (Q1, Q2, Q3, and Q4) according to the quartiles of SUA levels. The clinical data of each group were analysed and compared. Multivariate linear regression was employed to investigate the linear correlation between SUA levels and baPWV, and subgroup analyses were performed. There were differences in sex ratio, body mass index (BMI), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), homocysteine (HCY), and baPWV levels between the four groups. After adjustment for confounders, a significant linear correlation between SUA and baPWV remained, with baPWV increasing by 0.519 cm/s for every 1 mmol/L increase in SUA (beta=0.519, 95%CI: 0.176-0.862, P = 0.003). BaPWV was significantly higher in the Q4 group compared with the lowest Q1 group (beta=137.043, 95%CI: 43.574-230.511, P = 0.004). Subgroup analysis showed that the positive correlation between SUA and baPWV was more significant in the subgroups of males, moderate-to-severe psoriasis, no history of hypertension, no history of hyperlipidaemia, non-smokers and BMI >= 24 kg/m2. In patients with psoriasis, high SUA is associated with increased baPWV. Early screening and intervention of cardiovascular risk should be emphasised. Further studies are needed to establish a causal relationship and to guide treatment.