Pregabalin for chronic cough due to lung cancer: randomized, double-blind, placebo-controlled trial

被引：0

作者：

Noronha, Vanita ^{[1
]}

Menon, Nandini ^{[1
]}

Patil, Vijay M. ^{[2
]}

Shah, Minit ^{[1
]}

Joshi, Amit ^{[1
]}

Shah, Srushti ^{[1
]}

Nawale, Kavita ^{[1
]}

Surve, Rohan ^{[1
]}

Bafna, Gunj ^{[3
]}

Jogdhankar, Shweta ^{[1
]}

Shelar, Priyanka ^{[1
]}

Shetake, Ankush ^{[1
]}

Singh, Ashish ^{[1
]}

Salian, Sushmita ^{[1
]}

Jadhav, Pundlik ^{[1
]}

Shah, Hetakshi ^{[1
]}

Mer, Neha ^{[1
]}

Vohra, Ananya ^{[4
]}

Majumdar, Swaratika ^{[1
,5
]}

Banavali, Shripad ^{[1
]}

Badwe, Rajendra ^{[1
]}

Prabhash, Kumar ^{[1
]}

机构：

[1] Homi Bhabha Natl Inst HBNI, Tata Mem Ctr, Dept Med Oncol, Mumbai, India

[2] P D Hinduja Hosp & Med Res Ctr, Dept Med Oncol, Mumbai, India

[3] Sunrise Oncol Ctr, Dept Med Oncol, Mumbai, India

[4] Childrens Hosp Philadelphia, Dept Leukodystrophy Ctr Neurol, Philadelphia, PA USA

[5] Mazumdar Shaw Med Ctr, Consultant Med Oncologist, Bengaluru, India

来源：

BRITISH JOURNAL OF CANCER | 2025年 / 132卷 / 01期

关键词：

REFRACTORY CHRONIC COUGH; QUALITY-OF-LIFE; SYMPTOM BURDEN; APREPITANT; EFFICACY; THERAPY; PAIN;

D O I：

10.1038/s41416-024-02913-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundDeveloping effective therapies for cough in lung cancer is an unmet need Neuromodulators like pregabalin may act centrally as cough suppressants.MethodsRandomized double-blind placebo-controlled study in patients with locally advanced/metastatic lung cancer and at least 2 weeks of moderate or severe cough. Randomization was 1:1 to pregabalin 300 mg orally daily or matching placebo, both administered for 9 weeks. Primary endpoint was the change in cough severity as measured by the difference in VAS scores.ResultsBetween Jul 2022 and Dec 2023, we enrolled 166 patients: 83 to each arm. Baseline cough severity was grade 2 in 128 (77.1%) and grade 3 in 38 (22.9%) patients; median cough duration was 12 weeks (IQR, 6-20). Systemic cancer-directed therapy was started in 78 (94.0%) and 72 (86.7%) patients in the pregabalin and placebo arms, respectively; P = 0.187. The mean (SD) VAS score (in mm) decreased from 71.58 (14.99) at baseline, to 45.54 (26.60) on day 7, and 22.27 (24.20) by week 9 in the pregabalin arm; and 71.75 (17.58), 46.35 (25.00), and 23.08 (22.42), respectively in the placebo arm; P = 0.877.ConclusionPregabalin does not significantly decrease cough in patients with lung cancer. Systemic cancer-directed therapy is the most effective antitussive.Clinical trial registrationName of the registry: Clinical Trials Registry India Registration number: CTRI/2020/11/029275 Website: www.ctri.nic.in

引用

页码：58 / 68

页数：11

共 39 条

[1]

accessdata.fda.gov, About Us

[2] THE EORTC QLQ-LC13 - A MODULAR SUPPLEMENT TO THE EORTC CORE QUALITY-OF-LIFE QUESTIONNAIRE (QLQ-C30) FOR USE IN LUNG-CANCER CLINICAL-TRIALS [J].

BERGMAN, B ;

AARONSON, NK ;

AHMEDZAI, S ;

KAASA, S ;

SULLIVAN, M .

EUROPEAN JOURNAL OF CANCER, 1994, 30A (05) :635-642

[3] Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ) [J].

Birring, SS ;

Prudon, B ;

Carr, AJ ;

Singh, SJ ;

Morgan, MDL ;

Pavord, ID .

THORAX, 2003, 58 (04) :339-343

[4] Encoding of the cough reflex in anesthetized guinea pigs [J].

Canning, Brendan J. ;

Mori, Nanako .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2011, 300 (02) :R369-R377

[5] Central regulation of the cough reflex: Therapeutic implications [J].

Canning, Brendan J. .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2009, 22 (02) :75-81

[6]

ctep.cancer.gov, About us

[7] A New Treatment Option for Laryngeal Sensory Neuropathy [J].

Halum, Stacey L. ;

Sycamore, David L. ;

McRae, Bryan R. .

LARYNGOSCOPE, 2009, 119 (09) :1844-1847

[8] A cross sectional study to determine the prevalence of cough and its impact in patients with lung cancer: a patient unmet need [J].

Harle, Amelie ;

Molassiotis, Alex ;

Buffin, Oliver ;

Burnham, Jack ;

Smith, Jaclyn ;

Yorke, Janelle ;

Blackhall, Fiona H. .

BMC CANCER, 2020, 20 (01)

[9] Cough in Patients With Lung Cancer A Longitudinal Observational Study of Characterization and Clinical Associations [J].

Harle, Amelie S. M. ;

Blackhall, Fiona H. ;

Molassiotis, Alex ;

Yorke, Lanelle ;

Dockry, Rachel ;

Holt, Kimberley J. ;

Yuill, Danielle ;

Baker, Katie ;

Smith, Jaclyn A. .

CHEST, 2019, 155 (01) :103-113

[10] The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study [J].

Iyer, Shrividya ;

Roughley, Adam ;

Rider, Alex ;

Taylor-Stokes, Gavin .

SUPPORTIVE CARE IN CANCER, 2014, 22 (01) :181-187

← 1 2 3 4 →