Integrated Utilization of Functional Nanomaterials for COVID-19 Monitoring, Prevention, and Diagnostic Strategies

Purpose: The integration of functional nanomaterials signifies a transformative method in tackling the multifaceted challenges presented by COVID-19. This review aims to evaluate the potential of functional nanomaterials for COVID-19 prevention, diagnosis, and monitoring approaches. Method: This systematic review synthesized findings from extensive database searches across various platforms: Web of Science, Science Direct, Taylor & Francis, Sage Publications, PubMed, American Chemical Society, Springer Journals, Hindawi, Wiley Online Library, Royal Society of Chemistry and Google Scholar. It focused on pertinent keywords such as coronavirus, nanotechnology, surface-enhanced Raman spectroscopy and pandemic. From an initial pool of 200 publications, however, around 100 papers published within the last five years were selected for comprehensive analysis. Although the selection was limited, it reflects a significant effort to capture the most impactful research in the field. Result and conclusion: The global ramifications of SARS-CoV-2 have revealed considerable shortcomings in conventional disease management strategies. This necessitates innovative solutions that go beyond traditional quarantine measures, testing protocols, treatment modalities and support systems for vulnerable populations. Nanotechnology emerges as a promising domain by conceptualizing viruses as meta-stable nanoparticles and leveraging this understanding to develop advanced functional nanomaterials. These sophisticated materials exhibit remarkable potential in creating cost-effective detection platforms, enhancing the performance of personal protective equipment and improving therapeutic interventions. This review underscores the importance of integrating nanotechnology into global health efforts, offering a comprehensive exploration of its potential to mitigate the ongoing crisis and safeguard public health worldwide. © The Author(s), under exclusive licence to The Brazilian Society of Biomedical Engineering 2025.