Reaction of 6Н-5-(4-Fluorophenyl)-3-(2-pyridyl)-1,2,4-triazine with 4,5-Difluoro-1,2-dehydrobenzene

被引：0
作者：
Rammohan, A. [1 ]
Krinochkin, A. P. [1 ,2 ]
Sayfutdinova, Yu. M. [1 ]
Shtaitz, Y. K. [1 ,2 ]
Potapova, S. S. [1 ,2 ]
Slepukhin, P. A. [1 ,2 ]
Gaviko, V. S. [1 ,3 ]
Kopchuk, D. S. [1 ,2 ]
Zyryanov, G. V. [1 ,2 ]
Chupakhin, O. N. [1 ,2 ]
机构：
[1] Ural Fed Univ, Ekaterinburg 620002, Russia
[2] Russian Acad Sci, Inst Organ Synth, Ural Branch, Ekaterinburg 620219, Russia
[3] Russian Acad Sci, Inst Phys Met, Ural Branch, Ekaterinburg 620108, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2024年 / 94卷 / 09期
关键词：
1,2,4-triazines; 4,5-difluoro-1,2-dehydrobenzene; pyrido[1,2-<italic>a</italic>]indoles; domino transformation; 1,6-dihydro-1,2,4-triazine-6-ols; 1<italic>H</italic>-1,2,4-triazoles; X-ray diffraction analysis; DIELS-ALDER REACTION; POTASSIUM-AMIDE; 1,2,4-TRIAZINES; DIENOPHILES; COMPLEXES; AMINATION; DEMAND; ROUTE;
D O I：
10.1134/S1070363224090056
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AbstractThe reaction of C6-unsubstituted 5-aryl-3-(2-pyridyl)-1,2,4-triazine with generated in situ difluoroaryne intermediate (4,5-difluoro-1,2-dehydrobenzene), previously unused for this aim, was studied. New transformations of the 1,2,4-triazine nucleus were discovered, which lead, along with the domino transformation product (10-(1,2,3-triazole-3-yl)pyrido[1,2-a]indole) natural for this transformation, to the formation of unexpected products, namely 1,3,5-tris-substituted 1,6-dihydro-1,2,4-triazin-6-ol and 1H-1,2,4-triazole. The structure of the products was confirmed by physicochemical methods, including X-ray diffraction analysis.
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页码：2255 / 2263
页数：9
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