Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway

被引：0

作者：

Jiang, Wenyi ^{[1
]}

He, Zhengyou ^{[2
]}

Yao, Ruijiao ^{[1
]}

Xiao, Wenyan ^{[1
]}

Chen, Zhiyang ^{[2
]}

Zeng, Xia ^{[2
]}

Zheng, Miao ^{[2
]}

Wang, Jing ^{[2
]}

Li, Jia ^{[2
]}

Jiang, Yong ^{[2
]}

机构：

[1] Chengdu Univ, Sch Food & Biol Engn, Chengdu 610106, Peoples R China

[2] Chengdu Univ, Sichuan Ind Inst Antibiot, Sch Pharm, Chengdu 610106, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2025年 / 79卷 / 01期

关键词：

Eucommiae cortex; CKD; TGF-beta; 1/Smad; Renal fibrosis; CHRONIC KIDNEY-DISEASE; NATURAL REGULATOR;

D O I：

10.1007/s11418-024-01848-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Research into the potential therapeutic benefits of herbal remedies for treating chronic kidney disease (CKD), a condition marked by renal fibrosis and persistent inflammation, has become popular. Eucommiae cortex (EC) is a vital herb for strengthening bones and muscles and tonifying the kidneys and liver. In the study, C57 BL/6 mice were given a diet containing 0.2% adenine to create a CKD model. The findings demonstrated that exogenous EC supplementation successfully decreased the levels of creatinine and urea nitrogen, down-regulated the TGF-beta 1/Smad signaling pathway's expression levels of TGF-beta 1, alpha-SMA, Smad3, and phospho-Smad3, and prevented renal fibrosis. Consequently, it was determined that EC might have a nephroprotective impact.

引用

页码：170 / 179

页数：10

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