Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer

被引：0

作者：

Zhang, Lijie ^{[1
]}

Zhao, Xiaomin ^{[1
]}

Gao, Xianghong ^{[1
]}

Qin, Hao ^{[1
]}

Chen, Feng ^{[2
]}

Lin, Zhijuan ^{[1
]}

机构：

[1] Shandong Second Med Univ, Key Lab Immunol Univ Shandong Prov, Sch Basic Med Sci, Weifang 261053, Shandong, Peoples R China

[2] Shandong Second Med Univ, Weifang Hosp Tradit Chinese Med, Weifang 261001, Shandong, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2025年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

LncRNA; CircRNA; HMGA1; Tumorigenesis; Targeted therapy; RENAL-CELL CARCINOMA; AT-HOOK; TARGETING HMGA1; GASTRIC-CANCER; INHIBITS PROLIFERATION; ENDOMETRIAL CARCINOMA; MALIGNANT PHENOTYPE; OSTEOSARCOMA CELLS; MIGRATION; EXPRESSION;

D O I：

10.1186/s12935-025-03713-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and is highly expressed in the embryonic period and many tumors. It is involved in multiple hallmarks of tumors and affects the occurrence and progression of tumors. Nowadays, many non-coding RNAs (ncRNAs), such as miRNA, lncRNA, and circRNA, have been found to play a crucial role in HMGA1 regulation. Moreover, some ncRNAs are reported to be the downstream effectors of HMGA1. They interact with each other to affect multiple hallmarks of cancer and targeting ncRNAs or HMGA1 may provide potential strategies for cancer therapy. In this review, we give an overview of recent studies describing the crosstalk between oncogenic HMGA1 and ncRNAs. We also point out the impact of this interaction on the biological behavior of tumors and their potential in tumor therapy in order to offer potential implications and directions for both basic science and clinical applications.

引用

页数：13

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