Cutting edge: ferroptosis in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis and therapy

被引:0
作者
El-Sehrawy, Amr Ali Mohamed Abdelgawwad [1 ]
Rashid, Teeba Ammar [2 ]
Ullah, Muhammad Ikram [3 ]
Uthirapathy, Subasini [4 ]
Ganesan, Subbulakshmi [5 ]
Singh, Abhayveer [6 ]
Devi, Anita [7 ]
Joshi, Kamal Kant [8 ,9 ]
Jasim, Ahmed Salman [10 ]
Kadhim, Abed J. [11 ]
机构
[1] Mansoura Univ, Internal Med Diabet Endocrinol & Metab, Mansoura, Egypt
[2] Univ Al Maarif, Coll Hlth & Med Technol, Dept Med Labs Tech, Anbar, Iraq
[3] Jouf Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Sakaka 72388, Aljouf, Saudi Arabia
[4] Tishk Int Univ, Fac Pharm, Erbil, Kurdistan Regio, Iraq
[5] JAIN, Sch Sci, Dept Chem & Biochem, Bangalore, Karnataka, India
[6] Chitkara Univ, Chitkara Univ Inst Engn & Technol, Ctr Res Impact & Outcome, Rajpura 140401, Punjab, India
[7] Chandigarh Grp Coll Jhanjeri, Chandigarh Engn Coll, Dept Chem, Mohali 140307, Punjab, India
[8] Graph Era Hill Univ, Dept Allied Sci, Dehra Dun 248002, Uttarakhand, India
[9] Graph Era Deemed Be Univ, Dehra Dun, Uttarakhand, India
[10] Al Mustaqbal Univ, Coll Hlth & Med Tech, Radiol Tech Dept, Babylon 5100, Iraq
[11] AL Nisour Univ Coll, Dept Med Engn, Baghdad, Iraq
关键词
MASLD; Ferroptosis; Iron; Lipid; Pathogenesis; SIMPLE NONINVASIVE INDEX; SIGNIFICANT FIBROSIS; OXIDATIVE STRESS; TARGET; RNA; FERROPORTIN; MECHANISM; DIAGNOSIS; BINDING; PREDICT;
D O I
10.1007/s10142-025-01579-0
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Ferroptosis denotes a distinct form of controlled cell death marked by substantial iron buildup and significant lipid peroxidation, playing a crucial role in several disease processes linked to cell death. Given the liver's essential functions in iron and lipid metabolism and its vulnerability to oxidative damage, more research has investigated the correlation between ferroptosis and numerous hepatic diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD). NAFLD has arisen as a worldwide public health concern due to elevated morbidity and high death rates. The pathogenesis of MASLD remains incompletely elucidated. Recent data suggests that ferroptosis is crucial in the pathophysiology of MASLD; nevertheless, the specific processes by which ferroptosis influences MASLD remain unclear. The present review summarizes the molecular processes of ferroptosis and its intricate regulatory networks, outlines the differing impacts of ferroptosis at different stages of MASLD, and examines possible approaches targeting ferroptosis for the therapy of MASLD, suggesting a novel approach for its management.
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页数:18
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