Association of Parity with Type 2 Diabetes Mellitus in Japan

被引：0

作者：

Wang, Hongxin ^{[1
]}

Iwama, Noriyuki ^{[1
,2
,3
]}

Yuwaki, Keiichi ^{[4
]}

Nakamichi, You ^{[4
]}

Hamada, Hirotaka ^{[1
]}

Tomita, Hasumi ^{[1
]}

Tagami, Kazuma ^{[1
]}

Kudo, Rie ^{[1
]}

Kumagai, Natsumi ^{[1
]}

Metoki, Hirohito ^{[3
,5
]}

Nakaya, Naoki ^{[3
]}

Hozawa, Atsushi ^{[3
]}

Kuriyama, Shinichi ^{[6
,7
,8
]}

Yaegashi, Nobuo ^{[1
,2
,3
,8
]}

Saito, Masatoshi ^{[1
,2
,9
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Obstet & Gynecol, 1-1 Seiryomachi, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Womens Hlth Care Med Sci, Grad Sch Med, 1-1 Seiryomachi, Sendai, Miyagi 9808574, Japan

[3] Tohoku Univ, Tohoku Med Megabank Org, 2-1 Seiryomachi, Sendai, Miyagi, Japan

[4] Dai Ichi Life Insurance Co Ltd, Underwriting & Med Dept, 3-2-3 Toyosu,Koto Ku, Tokyo, Japan

[5] Tohoku Med Pharmaceut Univ, Div Publ Hlth Hyg & Epidemiol, 1-15-1 Fukumuro, Sendai, Miyagi, Japan

[6] Tohoku Univ, Div Mol Epidemiol, Grad Sch Med, 1-1 Seiryomachi, Sendai, Miyagi, Japan

[7] Tohoku Univ, Int Res Inst Disaster Sci, 468-1 Aramaki, Sendai, Miyagi, Japan

[8] Tohoku Univ, Environm & Genome Res Ctr, Grad Sch Med, 2-1 Seiryomachi, Sendai, Miyagi, Japan

[9] Tohoku Univ, Dept Maternal & Fetal Therapeut, Grad Sch Med, 1-1 Seiryomachi, Sendai, Miyagi, Japan

来源：

REPRODUCTIVE SCIENCES | 2025年 / 32卷 / 02期

关键词：

Parity; Diabetes mellitus; Gestational diabetes mellitus; Cohort study; CORONARY-HEART-DISEASE; INCREASED RISK; GLUCOSE-TOLERANCE; 64; COHORTS; WOMEN; HEALTH; MEN; METAANALYSIS; INDIVIDUALS; PREVALENCE;

D O I：

10.1007/s43032-024-01752-z

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This study investigates the association between parity and type 2 diabetes mellitus (T2DM) in Japanese women, considering the clinical history of gestational diabetes mellitus (GDM) and menopausal status, which are known risk factors for T2DM. Overall, 30,116 Japanese women (6,588 premenopausal and 23,528 postmenopausal) were included in this cross-sectional study. They were divided into two groups according to menopausal status (premenopausal and postmenopausal women), and the association between parity and T2DM was evaluated using a multiple logistic regression model with possible confounders, including a clinical history of GDM. The association between parity and T2DM was not statistically significant in premenopausal women. In contrast, a linear graded association between parity and T2DM was found in postmenopausal women. Furthermore, the association between parity and T2DM in postmenopausal women was attenuated after adjusting for body weight gain after the age of 20 years. A clinical history of GDM was significantly associated with a high risk for T2DM, regardless of adjustment for body weight gain after the age of 20 years in both premenopausal and postmenopausal women. Parity is associated with an increased risk of T2DM in postmenopausal women but not in premenopausal women. Maintaining appropriate body weight would be beneficial in attenuating the risk of T2DM in postmenopausal women. A clinical history of GDM is a risk factor for T2DM in both pre- and postmenopausal women; therefore, women with a clinical history of GDM require continuous medical care to survey for T2DM.

引用

页码：366 / 381

页数：16

共 39 条

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